Laryngeal tumor volume as a predictor for thyroid cartilage penetration

Background Review of laryngectomy specimens demonstrated that preoperative CT scanning is suboptimal in predicting both thyroid cartilage penetration and extralaryngeal spread. We investigated the association between the CT‐based gross tumor volume (GTV) with pathologic evidence of thyroid cartilage...

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Bibliographic Details
Published in:Head & neck 2013-03, Vol.35 (3), p.426-430
Main Authors: Kats, Svetlana S., Muller, Susan, Aiken, Ashley, Hudgins, Patricia A., Wadsworth, J. Trad, Shin, Dong M., Khuri, Fadlo, Beitler, Jonathan J.
Format: Article
Language:English
Subjects:
Carcinoma, Squamous Cell - diagnostic imaging
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - surgery
Cervical cancer
glottic cancer
Humans
Laryngeal Neoplasms - diagnostic imaging
Laryngeal Neoplasms - pathology
Laryngeal Neoplasms - surgery
laryngectomy
Larynx
Larynx - diagnostic imaging
Larynx - pathology
larynx cancer
Middle Aged
Neoplasm Invasiveness
Retrospective Studies
thyroid cartilage
Thyroid Cartilage - diagnostic imaging
Thyroid Cartilage - pathology
Tomography, X-Ray Computed
Tumor Burden
tumor volume
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Summary:Background Review of laryngectomy specimens demonstrated that preoperative CT scanning is suboptimal in predicting both thyroid cartilage penetration and extralaryngeal spread. We investigated the association between the CT‐based gross tumor volume (GTV) with pathologic evidence of thyroid cartilage penetration among patients undergoing laryngectomy for squamous cell carcinoma (SCC) of the larynx. Methods Ninety‐four patients were identified who underwent total laryngectomy for SCC of the larynx. GTV, as defined by preoperative diagnostic CT scan, was contoured and analyzed using treatment‐planning software. Results Among the 49 nonirradiated patients, the mean GTVs of patients with (n = 15) and without (n = 34) thyroid cartilage penetration was 60.1 and 28.0 cm3 (p = .004). When the nonirradiated patients were divided into 3 GTV groups (≤25 cm3, 25–50 cm3, >50 cm3), the rates of thyroid cartilage penetration were 23%, 17%, and 78%, respectively (p = .003). Conclusions Laryngeal tumor volume is associated with pathologic evidence of thyroid cartilage penetration in nonirradiated patients. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.22995