Progressive Intracranial Fusiform Aneurysms and T-Cell Immunodeficiency

Abstract In the pediatric population, intracranial fusiform aneurysms have been associated with human immunodeficiency virus/acquired immunodeficiency syndrome and rarely with opportunistic infections related to other immunodeficiencies. The HIV virus and other infectious organisms have been implica...

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Bibliographic Details
Published in:Pediatric neurology 2013-02, Vol.48 (2), p.130-134
Main Authors: Piantino, Juan A., MD, Goldenberg, Fernando D., MD, Pytel, Peter, MD, Wagner-Weiner, Linda, MD, Ansari, Sameer A., MD, PhD
Format: Article
Language:English
Subjects:
Adolescent
Aneurysm
Brain - diagnostic imaging
Brain - immunology
Brain - pathology
Disease Progression
Fatal Outcome
Female
Human immunodeficiency virus
Humans
Immunodeficiency
Immunologic Deficiency Syndromes - diagnostic imaging
Immunologic Deficiency Syndromes - immunology
Immunologic Deficiency Syndromes - pathology
Inflammation
Intracranial Aneurysm - diagnostic imaging
Intracranial Aneurysm - immunology
Intracranial Aneurysm - pathology
Lymphocytes T
Neurology
Opportunist infection
Pediatrics
Radiography
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Summary:Abstract In the pediatric population, intracranial fusiform aneurysms have been associated with human immunodeficiency virus/acquired immunodeficiency syndrome and rarely with opportunistic infections related to other immunodeficiencies. The HIV virus and other infectious organisms have been implicated in the pathophysiology of these aneurysms. We present a child with T-cell immunodeficiency but no evidence of human immunodeficiency virus or opportunistic intracranial infections that developed progressive bilateral fusiform intracranial aneurysms. Our findings suggest a role of immunodeficiency or inflammation in the formation of some intracranial aneurysms.
ISSN:0887-8994
1873-5150
DOI:10.1016/j.pediatrneurol.2012.10.004