Ultraviolet Radiation-induced Suppression of Contact Hypersensitivity in Relation to Padimate O and Oxybenzone

Contact hypersensitivity (CHS) in mice can be induced by cutaneous sensitization followed by elicitation via ear-painting with trinitrochlorobenzene (TNCB). This CHS reaction is systemic and can be suppressed by exposure of mice to suberythemogenic doses of 280-315nm radiation. In this study, we inv...

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Bibliographic Details
Published in:Journal of investigative dermatology 1989-03, Vol.92 (3), p.337-341
Main Authors: Fisher, Michael S., Menter, Julian M., Willis, Isaac
Format: Article
Language:English
Subjects:
4-Aminobenzoic Acid - pharmacology
Aminobenzoates - pharmacology
Animals
Benzophenones - pharmacology
Contact dermatitis
Dermatitis, Contact - immunology
Dermatology
Dose-Response Relationship, Radiation
Erythema
Erythema - etiology
Erythema - immunology
Immune Tolerance - drug effects
Immune Tolerance - radiation effects
Mice
Mice, Hairless
para-Aminobenzoates
Sunscreening Agents - pharmacology
Sunscreens
trinitrochlorobenzene
U.V. radiation
Ultraviolet Rays
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Summary:Contact hypersensitivity (CHS) in mice can be induced by cutaneous sensitization followed by elicitation via ear-painting with trinitrochlorobenzene (TNCB). This CHS reaction is systemic and can be suppressed by exposure of mice to suberythemogenic doses of 280-315nm radiation. In this study, we investigated whether a commercially available water-resistant sunscreen, either SPF-6 or SPF-15, containing Padimate O (UVB absorber) and oxybenzone (UVA absorber), was effective in preventing systemic suppression of CHS induced by either FS36 sunlamp exposure or solar simulating radiation. We observed that these two sunscreen preparations were totally incapable of preventing the immunologic suppression of contact hypersensitivity by UV radiation. These results indicate that application of sunscreen does not retard the development of suppression of CHS following repeated UV exposure under conditions where erythema is not clinically observed. Thus, erythema may not be a good end point for assessing systemic immune suppression and its consequences.
ISSN:0022-202X
1523-1747
DOI:10.1111/1523-1747.ep12277156