Nuclear factor-E2 (Nrf2) is regulated through the differential activation of ERK1/2 and PKC α/βII by Gymnasterkoreayne B

Highlights ► Gymnasterkoreayne B was used to elucidate upstream signaling for Nrf2 regulation. ► We confirmed that GKB significantly increases expression of Nrf2 in HCT116 cells. ► We examined changes in various kinases in HCT116 cells treated with GKB. ► We observed that ERK and PKC are involved in...

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Bibliographic Details
Published in:Cancer letters 2013-04, Vol.330 (2), p.225-232
Main Authors: Lee, Kyung-Mi, Kang, Kyungsu, Lee, Saet Byoul, Nho, Chu Won
Format: Article
Language:English
Subjects:
Active Transport, Cell Nucleus
Anticarcinogenic Agents - pharmacology
ERK
Gymnasterkoreayne B
HCT116 Cells
Hematology, Oncology and Palliative Medicine
Humans
Mitogen-Activated Protein Kinase 1 - physiology
Mitogen-Activated Protein Kinase 3 - physiology
NAD(P)H Dehydrogenase (Quinone) - metabolism
NF-E2-Related Factor 2 - physiology
NQO-1
Nrf2
PKC
Polyacetylenes - pharmacology
Protein Kinase C - physiology
Protein Kinase C beta
Protein Kinase C-alpha - physiology
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Summary:Highlights ► Gymnasterkoreayne B was used to elucidate upstream signaling for Nrf2 regulation. ► We confirmed that GKB significantly increases expression of Nrf2 in HCT116 cells. ► We examined changes in various kinases in HCT116 cells treated with GKB. ► We observed that ERK and PKC are involved in the activation of Nrf2 by GKB. ► GKB activates Nrf2 by differential regulation of ERK and PKC pathways.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2012.11.053