Evolution of Trends in the Live Kidney Transplant Donor-Recipient Relationship

Abstract Objective This study examined the changing demographics and age profile between living donors and their recipients. A 46-year review of living donor renal transplants in a single transplant center was performed. Patients The study included 923 consecutive living donor renal transplants from...

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Bibliographic Details
Published in:Transplantation proceedings 2013, Vol.45 (1), p.57-64
Main Authors: Nelson, E.W, Mone, M.C, Nelson, E.T, Hansen, H.J, Gawlick, U, Alder, S
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Child
Child, Preschool
Female
Humans
Infant
Kidney Failure, Chronic - therapy
Kidney Transplantation - methods
Kidney Transplantation - trends
Living Donors
Male
Middle Aged
Parents
Regression Analysis
Siblings
Spouses
Surgery
Tissue and Organ Procurement - methods
Young Adult
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Summary:Abstract Objective This study examined the changing demographics and age profile between living donors and their recipients. A 46-year review of living donor renal transplants in a single transplant center was performed. Patients The study included 923 consecutive living donor renal transplants from January 1966 until December 2011. Results These 923 living donor kidneys transplants represent 41% of all transplants performed during this 46-year review. The majority involved sibling donation (39.5%) followed by parent to child (32.5%). Dividing the 46-year timeframe into quartiles, the mean age of donors has remained stable at 39.3 ± 10.9 years. In contrast, the mean age of recipients has trended upwards, from 28 ± 10.7 years in the first quartile (1966–1978) to 37 ± 17.5 years in the latest quartile (2001–2011). This represents an increase every year of approximately 4 months ( P < .001). Over the same period, the difference between a given donor's age and their recipient's has decreased every year by approximately 4 months ( P < .001). In a linear regression model of donor-recipient categories and their age difference over time, we found that both the child-to-parent and grandchild-to-grandparent groups had the largest effect on the donor-recipient age difference when compared to the classic parent-to-child relationship. Conclusion This review of center-specific data shows that the difference in the age of the donor to their recipient has been narrowing over time. We have determined that this is primarily due to changes in donor-recipient demographics with an increasing number of younger donors to older recipients. Although the medical risks to donors living with a single kidney have yet to be shown different than that of the general population, the increasing volume of donors who are younger and those with no relation to the recipient should prompt closer follow-up within the transplantation medical community.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2012.08.006