Pediatric Case Report on Magnetic Resonance Imaging/Transrectal Ultrasound-fusion Biopsy of Rhabdomyosarcoma of the Bladder/Prostate: A New Tool To Reduce Therapy-associated Morbidity?

Rhabdomyosarcomas are the most common soft tissue sarcomas in children. Here we present management of an 18-month-old boy with metastatic rhabdomyosarcoma of the bladder/prostate. After radiochemotherapy, high-spatial-resolution 3-Tesla multiparametric magnetic resonance imaging (MRI) showed regress...

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Published in:Urology (Ridgewood, N.J.) N.J.), 2013-02, Vol.81 (2), p.417-420
Main Authors: Kuru, Timur H, Roethke, Matthias C, Nyarangi-Dix, Joanne, Okouoyo, Stella, Stockklausner, Clemens, Schenk, Jens-Peter, Debus, Jürgen, Roth, Wilfried, Teber, Dogu, Pahernik, Sascha, Schlemmer, Heinz-Peter, Hohenfellner, Markus, Hadaschik, Boris A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chemoradiotherapy
Diseases of the osteoarticular system
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Endosonography
Humans
Infant
Lymphatic Metastasis
Magnetic Resonance Imaging
Male
Medical sciences
Nephrology. Urinary tract diseases
Patient Care Planning
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - pathology
Prostatic Neoplasms - therapy
Rhabdomyosarcoma - diagnosis
Rhabdomyosarcoma - secondary
Rhabdomyosarcoma - therapy
Tumors of striated muscle and skeleton
Urinary Bladder Neoplasms - diagnosis
Urinary Bladder Neoplasms - therapy
Urology
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Summary:Rhabdomyosarcomas are the most common soft tissue sarcomas in children. Here we present management of an 18-month-old boy with metastatic rhabdomyosarcoma of the bladder/prostate. After radiochemotherapy, high-spatial-resolution 3-Tesla multiparametric magnetic resonance imaging (MRI) showed regressive systemic disease but a residual mass at the right seminal vesicle. For histologic re-evaluation, 3-dimensional-controlled stereotactic MRI/transrectal ultrasound (TRUS)-fusion biopsy specimens were taken. Because histologic analysis showed nonvital tissue, a decision could be made against adjuvant radical cystoprostatectomy. Advanced 3-Tesla imaging and MRI/TRUS-fusion biopsies in children are feasible and represent an effective tool to examine suspicious pelvic lesions. Depending on histology, this can lead to a significant reduction of therapy-associated morbidity.
ISSN:0090-4295
1527-9995
DOI:10.1016/j.urology.2012.10.043