Comparison of cardiac autonomic functions among postmenopausal women with and without hormone replacement therapy, and premenopausal women

The aim of present study was comparison of cardiac autonomic status during different phases of reproductive life in women - in premenopausal women between proliferative and secretory phase, in postmenopausal women and in postmenopausal women receiving hormone replacement therapy (HRT). The study inc...

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Bibliographic Details
Published in:Indian journal of physiology and pharmacology 2011-10, Vol.55 (4), p.297-303
Main Authors: Gautam, Shikha, Shankar, Nilima, Tandon, Om Prakash, Goel, Neerja
Format: Article
Language:English
Subjects:
Adult
Autonomic Nervous System - physiology
Blood Pressure
Estrogen Replacement Therapy
Female
Heart - innervation
Heart Rate
Humans
Middle Aged
Postmenopause - physiology
Premenopause - physiology
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Summary:The aim of present study was comparison of cardiac autonomic status during different phases of reproductive life in women - in premenopausal women between proliferative and secretory phase, in postmenopausal women and in postmenopausal women receiving hormone replacement therapy (HRT). The study included 30 premenopausal women (Group 1) who were assessed in both proliferative (Group 1A) and secretory phase (Group 1B) of menstrual cycle, 30 postmenopausal women (Group 2) and 30 postmenopausal women on HRT (Group 3). Various autonomic function tests were done to assess parasympathetic and sympathetic functions. Results were obtained by ANOVA followed by Tukey test. The postmenopausal women (Group 2) showed increased sympathetic and decreased parasympathetic tone compared to premenopausal women (Group1). The women on HRT (Group 3) showed parasympathetic dominance and decrease in sympathetic activity compared to postmenopausal women (Group 2). Across the menstrual cycle, increased parasympathetic activity was seen in secretory phase while no change was observed in the sympathetic activity in the two phases.
ISSN:0019-5499