Total oxidative stress and antioxidant status in patients with carpal tunnel syndrome

Objectives Studies in the carpal tunnel syndrome (CTS) are supported ischemia-induced changes rather than inflammation of the flexor tenosynovium. In this study, total antioxidant status (TAS), total oxidative stress (TOS) and oxidative stress index (OSI) in patients with CTS has been investigated....

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Published in:Redox report : communications in free radical research 2012-11, Vol.17 (6), p.234-238
Main Authors: Demirkol, Ahmet, Uludag, Murat, Soran, Neslihan, Aksoy, Nurten, Gun, Kerem, Incebıyık, Serap, Gurgen, Ismahan, Vural, Mehmet, Altun, Yasşar, Kesiktas, Fatma Nur
Format: Article
Language:English
Subjects:
Adult
Antioxidant status
Antioxidants - analysis
Carpal tunnel syndrome
Carpal Tunnel Syndrome - blood
Carpal Tunnel Syndrome - etiology
Carpal Tunnel Syndrome - physiopathology
Connective Tissue - blood supply
Female
Humans
Male
Middle Aged
Neural Conduction
Oxidative Stress
Oxidative stress index
Pathogenesis
Physical Examination
Radial Nerve - physiopathology
Reperfusion Injury - complications
Reperfusion Injury - metabolism
Severity of Illness Index
Total oxidative stress
Wrist - blood supply
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Summary:Objectives Studies in the carpal tunnel syndrome (CTS) are supported ischemia-induced changes rather than inflammation of the flexor tenosynovium. In this study, total antioxidant status (TAS), total oxidative stress (TOS) and oxidative stress index (OSI) in patients with CTS has been investigated. Methods Forty-three patients (38 female and 5 male, 81 hands in total) diagnosed as CTS after the physical examination and electrophysiological findings included in study. The mean age of patients was 43.30 ± 10.49 years. Results Bilateral CTS in 38 (88%) patients and unilateral CTS in five patients were detected. Dominant hand was involved in all patients. The mean symptoms duration was 30.9 months (range, 5-67 months). TAS in patients with CTS was significantly lower compared with control (1.01 ± 0.14 versus 1.11 ± 0.20 mmol Trolox equiv./l), (P = 0.008). TOS and OSI in patients with CTS were significant higher compared with control (15.60 ± 7.03 versus 11.86 ± 2.18 µmol H2O2 equiv./l and 1.57 ± 0.72 versus 1.09 ± 0.28), (respectively P = 0.002 and
ISSN:1351-0002
1743-2928
DOI:10.1179/1351000212Y.0000000027