Accuracy of 18-F-FDG PET imaging in the follow up of endometrial cancer patients: Systematic review and meta-analysis of the literature

Abstract Objectives We reviewed the available literature on the accuracy of 18-F-FDG PET imaging in the follow up of the endometrial cancer patients and presented the results in systematic review and meta-analysis format Methods Medline, SCOPUS, ISI web of knowledge, Springer, and Science direct wer...

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Published in:Gynecologic oncology 2013-02, Vol.128 (2), p.397-404
Main Authors: Kadkhodayan, Sima, Shahriari, Sara, Treglia, Giorgio, Yousefi, Zohreh, Sadeghi, Ramin
Format: Article
Language:English
Subjects:
Endometrial cancer
Endometrial Neoplasms - diagnostic imaging
FDG
Female
Fluorodeoxyglucose F18
Follow-Up Studies
Hematology, Oncology and Palliative Medicine
Humans
Meta-analysis
Obstetrics and Gynecology
PET
Positron-Emission Tomography - methods
Positron-Emission Tomography - standards
Radiopharmaceuticals
Recurrence
Systematic review
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cited_by cdi_FETCH-LOGICAL-c480t-dcfa94f86863fd7cf30fbeb93a313a46c440cbf75ff45d14cfd486345bce4a483
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container_end_page 404
container_issue 2
container_start_page 397
container_title Gynecologic oncology
container_volume 128
creator Kadkhodayan, Sima
Shahriari, Sara
Treglia, Giorgio
Yousefi, Zohreh
Sadeghi, Ramin
description Abstract Objectives We reviewed the available literature on the accuracy of 18-F-FDG PET imaging in the follow up of the endometrial cancer patients and presented the results in systematic review and meta-analysis format Methods Medline, SCOPUS, ISI web of knowledge, Springer, and Science direct were searched with “PET AND Endometr*” as key words. All studies that evaluated the accuracy of 18-F-FDG imaging in the follow up of treated endometrial carcinoma were included if enough data could be extracted for calculation of sensitivity and/or specificity. Results Eleven studies (541 patients in total) were included in the analysis. Pooled diagnostic indices (patient basis) for detection of overall recurrence were as follows: sensitivity 95.8% [92.2–98.1], specificity 92.5% [89.3–94.9], positive likelihood ratio (LR +) 9.53 [6.52–13.91], negative likelihood ratio (LR −) 0.075 [0.044–0.128], and diagnostic odds ratio (DOR) 204 [91.97–453.5]. 18-F-FDG performance was better in studies conducted by PET/CT as compared to PET. The treatment plan changed in 22–35% of the studied patients. Conclusion 18-F-FDG PET is an accurate method for detection and localization of recurrence in post-therapy follow up of endometrial carcinoma. It can also change the treatment planning by localizing the recurrent lesions.
doi_str_mv 10.1016/j.ygyno.2012.10.022
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All studies that evaluated the accuracy of 18-F-FDG imaging in the follow up of treated endometrial carcinoma were included if enough data could be extracted for calculation of sensitivity and/or specificity. Results Eleven studies (541 patients in total) were included in the analysis. Pooled diagnostic indices (patient basis) for detection of overall recurrence were as follows: sensitivity 95.8% [92.2–98.1], specificity 92.5% [89.3–94.9], positive likelihood ratio (LR +) 9.53 [6.52–13.91], negative likelihood ratio (LR −) 0.075 [0.044–0.128], and diagnostic odds ratio (DOR) 204 [91.97–453.5]. 18-F-FDG performance was better in studies conducted by PET/CT as compared to PET. The treatment plan changed in 22–35% of the studied patients. Conclusion 18-F-FDG PET is an accurate method for detection and localization of recurrence in post-therapy follow up of endometrial carcinoma. It can also change the treatment planning by localizing the recurrent lesions.</description><identifier>ISSN: 0090-8258</identifier><identifier>EISSN: 1095-6859</identifier><identifier>DOI: 10.1016/j.ygyno.2012.10.022</identifier><identifier>PMID: 23107613</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Endometrial cancer ; Endometrial Neoplasms - diagnostic imaging ; FDG ; Female ; Fluorodeoxyglucose F18 ; Follow-Up Studies ; Hematology, Oncology and Palliative Medicine ; Humans ; Meta-analysis ; Obstetrics and Gynecology ; PET ; Positron-Emission Tomography - methods ; Positron-Emission Tomography - standards ; Radiopharmaceuticals ; Recurrence ; Systematic review</subject><ispartof>Gynecologic oncology, 2013-02, Vol.128 (2), p.397-404</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>Copyright © 2012 Elsevier Inc. 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All studies that evaluated the accuracy of 18-F-FDG imaging in the follow up of treated endometrial carcinoma were included if enough data could be extracted for calculation of sensitivity and/or specificity. Results Eleven studies (541 patients in total) were included in the analysis. Pooled diagnostic indices (patient basis) for detection of overall recurrence were as follows: sensitivity 95.8% [92.2–98.1], specificity 92.5% [89.3–94.9], positive likelihood ratio (LR +) 9.53 [6.52–13.91], negative likelihood ratio (LR −) 0.075 [0.044–0.128], and diagnostic odds ratio (DOR) 204 [91.97–453.5]. 18-F-FDG performance was better in studies conducted by PET/CT as compared to PET. The treatment plan changed in 22–35% of the studied patients. Conclusion 18-F-FDG PET is an accurate method for detection and localization of recurrence in post-therapy follow up of endometrial carcinoma. 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All studies that evaluated the accuracy of 18-F-FDG imaging in the follow up of treated endometrial carcinoma were included if enough data could be extracted for calculation of sensitivity and/or specificity. Results Eleven studies (541 patients in total) were included in the analysis. Pooled diagnostic indices (patient basis) for detection of overall recurrence were as follows: sensitivity 95.8% [92.2–98.1], specificity 92.5% [89.3–94.9], positive likelihood ratio (LR +) 9.53 [6.52–13.91], negative likelihood ratio (LR −) 0.075 [0.044–0.128], and diagnostic odds ratio (DOR) 204 [91.97–453.5]. 18-F-FDG performance was better in studies conducted by PET/CT as compared to PET. The treatment plan changed in 22–35% of the studied patients. Conclusion 18-F-FDG PET is an accurate method for detection and localization of recurrence in post-therapy follow up of endometrial carcinoma. 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subjects Endometrial cancer
Endometrial Neoplasms - diagnostic imaging
FDG
Female
Fluorodeoxyglucose F18
Follow-Up Studies
Hematology, Oncology and Palliative Medicine
Humans
Meta-analysis
Obstetrics and Gynecology
PET
Positron-Emission Tomography - methods
Positron-Emission Tomography - standards
Radiopharmaceuticals
Recurrence
Systematic review
title Accuracy of 18-F-FDG PET imaging in the follow up of endometrial cancer patients: Systematic review and meta-analysis of the literature
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