Loading…
Accuracy of 18-F-FDG PET imaging in the follow up of endometrial cancer patients: Systematic review and meta-analysis of the literature
Abstract Objectives We reviewed the available literature on the accuracy of 18-F-FDG PET imaging in the follow up of the endometrial cancer patients and presented the results in systematic review and meta-analysis format Methods Medline, SCOPUS, ISI web of knowledge, Springer, and Science direct wer...
Saved in:
Published in: | Gynecologic oncology 2013-02, Vol.128 (2), p.397-404 |
---|---|
Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Abstract Objectives We reviewed the available literature on the accuracy of 18-F-FDG PET imaging in the follow up of the endometrial cancer patients and presented the results in systematic review and meta-analysis format Methods Medline, SCOPUS, ISI web of knowledge, Springer, and Science direct were searched with “PET AND Endometr*” as key words. All studies that evaluated the accuracy of 18-F-FDG imaging in the follow up of treated endometrial carcinoma were included if enough data could be extracted for calculation of sensitivity and/or specificity. Results Eleven studies (541 patients in total) were included in the analysis. Pooled diagnostic indices (patient basis) for detection of overall recurrence were as follows: sensitivity 95.8% [92.2–98.1], specificity 92.5% [89.3–94.9], positive likelihood ratio (LR +) 9.53 [6.52–13.91], negative likelihood ratio (LR −) 0.075 [0.044–0.128], and diagnostic odds ratio (DOR) 204 [91.97–453.5]. 18-F-FDG performance was better in studies conducted by PET/CT as compared to PET. The treatment plan changed in 22–35% of the studied patients. Conclusion 18-F-FDG PET is an accurate method for detection and localization of recurrence in post-therapy follow up of endometrial carcinoma. It can also change the treatment planning by localizing the recurrent lesions. |
---|---|
ISSN: | 0090-8258 1095-6859 |
DOI: | 10.1016/j.ygyno.2012.10.022 |