Endoscopic management of Ewing's sarcoma of ethmoid sinus within the AMORE framework: A new paradigm

Abstract The Ablative surgery, MOulage brachytherapy and REconstruction) (AMORE) protocol developed in the Academic Medical Center of Amsterdam has been used successfully to treat sarcomas. The use of endoscopic surgery fits well within this framework. A 6-year-old boy presented with Ewing Sarcoma o...

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Bibliographic Details
Published in:International journal of pediatric otorhinolaryngology 2013-01, Vol.77 (1), p.139-143
Main Authors: Meccariello, Giuseppe, Merks, Johannes H.M, Pieters, Bradley R, van Furth, Wouter R, Saeed, Peerooz, Schoot, Reineke A, Freling, Nicole J.M, Bras, Johannes, Strackee, Simon D, Balm, Alfons J.M, Georgalas, Christos
Format: Article
Language:English
Subjects:
Bone Neoplasms - diagnosis
Bone Neoplasms - therapy
Bone tumor
Brachytherapy
Brachytherapy - methods
Chemoradiotherapy - methods
Child
Combined Modality Therapy
Endoscopic surgery
Endoscopy - methods
Ethmoid Sinus
Ewing sarcoma
Follow-Up Studies
Humans
Magnetic Resonance Imaging - methods
Male
Neoadjuvant Therapy - methods
Otolaryngology
Pediatrics
Reconstruction
Reconstructive Surgical Procedures - methods
Sarcoma, Ewing - diagnosis
Sarcoma, Ewing - therapy
Treatment Outcome
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Summary:Abstract The Ablative surgery, MOulage brachytherapy and REconstruction) (AMORE) protocol developed in the Academic Medical Center of Amsterdam has been used successfully to treat sarcomas. The use of endoscopic surgery fits well within this framework. A 6-year-old boy presented with Ewing Sarcoma of left ethmoid sinus closest to orbit. The patient underwent neoadjuvant chemotherapy followed by complete endoscopic resection, brachytherapy and reconstruction. Brachytherapy was administered by iridium catheters through limited Lynch–Howarth incision. Skull base defect was reconstructed with a galea flap. The use of endoscopic surgery complemented by neoadjuvant chemotherapy and brachytherapy might maximize tumor control while reducing morbidity.
ISSN:0165-5876
1872-8464
DOI:10.1016/j.ijporl.2012.09.023