CACNA1H antibodies associated with headache with neurological deficits and cerebrospinal fluid lymphocytosis (HaNDL)

Background Patients with the syndrome of headache with neurological deficits and lymphocytosis (HaNDL) typically present with recurrent and temporary attacks of neurological symptoms and cerebrospinal fluid lymphocytosis. Aim and methods To identify potential HaNDL‐associated antibodies directed aga...

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Bibliographic Details
Published in:Cephalalgia 2013-01, Vol.33 (2), p.123-129
Main Authors: Kürtüncü, Murat, Kaya, Dilaver, Zuliani, Luigi, Erdağ, Ece, İçöz, Sema, Uğurel, Elif, Çavuş, Filiz, Ayşit, Neşe, Birişik, Ömer, Vincent, Angela, Eraksoy, Mefkure, Vural, Burçak, Akman-Demir, Gülşen, Tüzün, Erdem
Format: Article
Language:English
Subjects:
Adult
Autoantibodies - blood
Autoantibodies - immunology
Calcium Channels, T-Type - blood
Calcium Channels, T-Type - immunology
Cerebrospinal Fluid - immunology
Female
Headache - blood
Headache - immunology
Humans
Lymphocytosis - cerebrospinal fluid
Lymphocytosis - immunology
Male
Middle Aged
Nervous System Diseases - blood
Nervous System Diseases - immunology
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Summary:Background Patients with the syndrome of headache with neurological deficits and lymphocytosis (HaNDL) typically present with recurrent and temporary attacks of neurological symptoms and cerebrospinal fluid lymphocytosis. Aim and methods To identify potential HaNDL‐associated antibodies directed against neuronal surface and/or synapse antigens, sera of four HaNDL patients and controls were screened with indirect immunohistochemistry, immunofluorescence, cell-based assay, radioimmunoassay, protein macroarray and enzyme-linked immunosorbent assay (ELISA). Results Although HaNDL sera did not yield antibodies to any of the well-characterized neuronal surface or synapse antigens, protein macroarray and ELISA studies showed high-titer antibodies to a subunit of the T-type voltage-gated calcium channel (VGCC), CACNA1H, in sera of two HaNDL patients. Conclusion Our results support the notion that ion channel autoimmunity might at least partially contribute to HaNDL pathogenesis and occurrence of neurological symptoms.
ISSN:0333-1024
1468-2982
DOI:10.1177/0333102412463494