Chemokine (CXC motif) ligand 9 serum levels in mixed cryoglobulinaemia are associated with circulating levels of IFN-gamma and TNF-alpha

No study evaluated circulating chemokine (CXC motif) ligand (CXCL)9 in 'patients with mixed cryoglobulinaemia and hepatitis C virus chronic infection' (MC+HCV). We aimed to measure CXCL9, IFN-γ and TNF-α in a series of MC+HCV to correlate these parameters to different clinical phenotypes....

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Published in:Clinical and experimental rheumatology 2012-11, Vol.30 (6), p.864-870
Main Authors: ANTONELLI, A, FALLAHI, P, FERRI, C, FERRARI, S. M, CORRADO, A, SEBASTIANI, M, MANFREDI, A, FRASCERRA, S, MICCOLI, M, ZIGNEGO, A. L, FERRANNINI, E
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Biomarkers - blood
Case-Control Studies
Chemokine CXCL9 - blood
Chi-Square Distribution
Cryoglobulinemia - blood
Cryoglobulinemia - immunology
Diseases of the osteoarticular system
Female
Hepatitis C, Chronic - blood
Hepatitis C, Chronic - immunology
Human viral diseases
Humans
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulinopathies
Immunopathology
Infectious diseases
Interferon-gamma - blood
Male
Medical sciences
Middle Aged
Multivariate Analysis
Tumor Necrosis Factor-alpha - blood
Up-Regulation
Vasculitis - blood
Vasculitis - immunology
Viral diseases
Viral hepatitis
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Summary:No study evaluated circulating chemokine (CXC motif) ligand (CXCL)9 in 'patients with mixed cryoglobulinaemia and hepatitis C virus chronic infection' (MC+HCV). We aimed to measure CXCL9, IFN-γ and TNF-α in a series of MC+HCV to correlate these parameters to different clinical phenotypes. Serum CXCL9, IFN-γ and TNF-α were assayed in 54 MC+HCV, in 54 patients with HCV chronic infection (HCV+) and in 54 sex- and age-matched controls. MC+HCV showed significantly higher mean CXCL9 than HCV+ patients (p=0.01; ANOVA) or controls (p=0.0001; ANOVA), in particular in 21 cryoglobulinaemic patients with active vasculitis compared to those without (p
ISSN:0392-856X
1593-098X