The proportion of tumor-stroma as a strong prognosticator for stage II and III colon cancer patients: validation in the VICTOR trial

The intra-tumor stroma percentage in colon cancer (CC) patients has previously been reported by our group as a strong independent prognostic parameter. Patients with a high stroma percentage within the primary tumor have a poor prognosis. Tissue samples from the most invasive part of the primary tum...

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Published in:Annals of oncology 2013-01, Vol.24 (1), p.179-185
Main Authors: Huijbers, A., Tollenaar, R.A.E.M., v Pelt, G.W., Zeestraten, E.C.M., Dutton, S., McConkey, C.C., Domingo, E., Smit, V.T.H.B.M., Midgley, R., Warren, B.F., Johnstone, E.C., Kerr, D.J., Mesker, W.E.
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Language:eng
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Summary:The intra-tumor stroma percentage in colon cancer (CC) patients has previously been reported by our group as a strong independent prognostic parameter. Patients with a high stroma percentage within the primary tumor have a poor prognosis. Tissue samples from the most invasive part of the primary tumor of 710 patients (52% Stage II, 48% Stage III) participating in the VICTOR trial were analyzed for their tumor-stroma percentage. Stroma-high (>50%) and stroma-low (≤50%) groups were evaluated with respect to survival times. Overall and disease-free survival times (OS and DFS) were significantly lower in the stroma-high group (OS P
ISSN:0923-7534
1569-8041