Self-formation of layered neural structures in three-dimensional culture of ES cells

Self-formation of layered neural structures in three-dimensional culture of ES cells

Highlights ► Rostral forebrain is a default differentiation direction of ES cell culture. ► ES cell-derived telencephalic progenitors generate cortical neurons. ► Sequential commitments of cortical neurons also occur in ES cell culture. ► 3D ES cell culture enables self-formation of layered cortical...

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Bibliographic Details
Published in:Current opinion in neurobiology 2012-10, Vol.22 (5), p.768-777
Main Authors: Eiraku, Mototsugu, Sasai, Yoshiki
Format: Article
Language:eng
Subjects:
Animals
Cell Culture Techniques - methods
Cell Differentiation
Cells, Cultured
Embryonic Stem Cells - physiology
Humans
Neurogenesis - physiology
Neurology
Psychiatry
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Summary:Highlights ► Rostral forebrain is a default differentiation direction of ES cell culture. ► ES cell-derived telencephalic progenitors generate cortical neurons. ► Sequential commitments of cortical neurons also occur in ES cell culture. ► 3D ES cell culture enables self-formation of layered cortical and retinal structure. ► Optic cup structure is also formed by self-organization in 3D ES cell culture.
ISSN:0959-4388
1873-6882