p53 Codon 72 arginine/proline polymorphism and cancer in Sudan

The aim of this report is to determine frequencies and associations of p53 codon 72 arg/pro polymorphism with different types of cancer in Sudan. p53 codon72 arg/pro polymorphism distribution and allele frequencies in 264 samples of different types of cancers were investigated using PCR. The results...

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Bibliographic Details
Published in:Molecular biology reports 2012-12, Vol.39 (12), p.10833-10836
Main Authors: Eltahir, Huda A., Adam, Ameera A. M., Yahia, Zeinab A., Ali, Noon F., Mursi, Dalia M., Higazi, Ashraaf M., Eid, Nahid A., Elhassan, Ahmed M., Mohammed, Hiba S., Ibrahim, Muntaser E.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Amino Acid Substitution - genetics
Animal Anatomy
Animal Biochemistry
Arginine
Biomedical and Life Sciences
Breast carcinoma
Burkitt's lymphoma
Cancer
Cervical cancer
Child
Child, Preschool
Codon - genetics
Codons
Confidence Intervals
Esophagus
Etiology
Female
Gene frequency
Gene Frequency - genetics
Genetic Predisposition to Disease
Genotype & phenotype
Histology
Humans
Life Sciences
Male
Middle Aged
Molecular biology
Morphology
Neoplasms - genetics
Odds Ratio
p53 protein
Polymerase chain reaction
Polymorphism
Population genetics
Proline
Sudan
Tumor Suppressor Protein p53 - genetics
Tumors
Young Adult
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Summary:The aim of this report is to determine frequencies and associations of p53 codon 72 arg/pro polymorphism with different types of cancer in Sudan. p53 codon72 arg/pro polymorphism distribution and allele frequencies in 264 samples of different types of cancers were investigated using PCR. The results were compared to 235 normal controls. The results indicated significant differences in frequency and genotype association between different types of cancers. Breast carcinoma patients most prominently showed excess of homozygous arg genotype as compared to controls with an Odd ratio (OR) of 19.44, 95 %CI: 6.6–78.3, P  
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-012-1978-0