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The impact of temperature and pump flow rate during selective cerebral perfusion on regional blood flow in piglets
Objective Ideal temperature and flow rate for selective cerebral perfusion (SCP) are not known. We examined regional organ perfusion in a piglet SCP model. Methods Three groups underwent SCP at 30 mL/kg/min at different temperatures (15°C, 25°C, and 32°C) and 4 groups remained at 25°C for SCP at dif...
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Published in: | The Journal of thoracic and cardiovascular surgery 2013, Vol.145 (1), p.188-195 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Objective Ideal temperature and flow rate for selective cerebral perfusion (SCP) are not known. We examined regional organ perfusion in a piglet SCP model. Methods Three groups underwent SCP at 30 mL/kg/min at different temperatures (15°C, 25°C, and 32°C) and 4 groups remained at 25°C for SCP at different flow rates (10, 30, 50 and 75 mL/kg/min). Fluorescent microspheres were injected at 5 minutes of normothermic cardiopulmonary bypass (CPB), immediately before SCP, SCP 45 minutes, SCP 90 minutes, and 2 hours after CPB. Brain and lower body organs were collected to examine regional blood flow (RBF, mL/min/g). Results At 2 hours after CPB, RBF of the 32°C group was higher than that of the 15°C group ( P |
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ISSN: | 0022-5223 1097-685X |
DOI: | 10.1016/j.jtcvs.2012.09.055 |