Circulating malondialdehyde-modified low-density lipoprotein levels are associated with the presence of thin-cap fibroatheromas determined by optical coherence tomography in coronary artery disease

The importance of oxidized low-density lipoprotein (oxLDL) has been implicated in the process of plaque rupture. However, few previous studies demonstrated the relationship between plaque morphology and oxLDL. We evaluated the relationship between coronary plaque vulnerability assessed by optical co...

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Bibliographic Details
Published in:European heart journal cardiovascular imaging 2013-01, Vol.14 (1), p.43-50
Main Authors: Matsuo, Yoshiki, Kubo, Takashi, Okumoto, Yasushi, Ishibashi, Kohei, Komukai, Kenichi, Tanimoto, Takashi, Ino, Yasushi, Kitabata, Hironori, Hirata, Kumiko, Imanishi, Toshio, Akagi, Hideharu, Akasaka, Takashi
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - blood
Acute Coronary Syndrome - diagnosis
Aged
Algorithms
Angina Pectoris - blood
Angina Pectoris - diagnosis
Angina Pectoris - etiology
Biomarkers - blood
Coronary Artery Disease - blood
Coronary Artery Disease - complications
Coronary Artery Disease - diagnosis
Feasibility Studies
Female
Humans
Lipoproteins, LDL - blood
Logistic Models
Male
Malondialdehyde - blood
Odds Ratio
Plaque, Atherosclerotic - diagnosis
Predictive Value of Tests
Prospective Studies
Risk Factors
Sensitivity and Specificity
Tomography, Optical Coherence
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Summary:The importance of oxidized low-density lipoprotein (oxLDL) has been implicated in the process of plaque rupture. However, few previous studies demonstrated the relationship between plaque morphology and oxLDL. We evaluated the relationship between coronary plaque vulnerability assessed by optical coherence tomography (OCT) and circulating malondialdehyde-modified low-density lipoprotein (MDA-LDL). OCT was used to determine plaque vulnerability in 102 patients with acute coronary syndrome (ACS; n = 53) and stable angina pectoris (SAP; n = 49). Circulating levels of MDA-LDL were measured by using enzyme-linked immunosorbent assay. Thin-cap fibroatheromas (TCFAs; defined as lipid-rich with plaque cap thickness
ISSN:2047-2404
2047-2412
DOI:10.1093/ehjci/jes094