Loading…
Antimicrobial and Antifouling Hydrogels Formed In Situ from Polycarbonate and Poly(ethylene glycol) via Michael Addition
A novel class of antimicrobial cationic polycarbonate/PEG hydrogels are designed and synthesized by Michael addition chemistry. These hydrogels demonstrate strong broad‐spectrum antimicrobial activities against various clinically isolated multidrug‐resistant microbes. Moreover, they exhibit nonfouli...
Saved in:
| Published in: | Advanced materials (Weinheim) 2012-12, Vol.24 (48), p.6484-6489 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c4495-73c1d131314843813ae672740aba81aa4faf56fac36519c595784317ef03fdde3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c4495-73c1d131314843813ae672740aba81aa4faf56fac36519c595784317ef03fdde3 |
| container_end_page | 6489 |
| container_issue | 48 |
| container_start_page | 6484 |
| container_title | Advanced materials (Weinheim) |
| container_volume | 24 |
| creator | Liu, Shao Qiong Yang, Chuan Huang, Yuan Ding, Xin Li, Yan Fan, Wei Min Hedrick, James L. Yang, Yi-Yan |
| description | A novel class of antimicrobial cationic polycarbonate/PEG hydrogels are designed and synthesized by Michael addition chemistry. These hydrogels demonstrate strong broad‐spectrum antimicrobial activities against various clinically isolated multidrug‐resistant microbes. Moreover, they exhibit nonfouling properties and prevent the substrate from microbial adhesion. These antimicrobial and antifouling gels are promising materials as catheter coatings and wound dressings to prevent infections. |
| doi_str_mv | 10.1002/adma.201202225 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1239057274</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1239057274</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4495-73c1d131314843813ae672740aba81aa4faf56fac36519c595784317ef03fdde3</originalsourceid><addsrcrecordid>eNqFkE1v1DAQhi0EotuWK0fkYzlk8UecxMeo0G61bUFqEdys2djeGpy42Elp_j0JW1a9oTmMNPO87-FB6C0lS0oI-wC6hSUjlBHGmHiBFlQwmuVEipdoQSQXmSzy6gAdpvSDECILUrxGB4wTWsmqWqDHuutd65oYNg48hk7j-WLD4F23xatRx7A1PuGzEFuj8UWHb1w_YBtDi78EPzYQN6GD3vzNzpcT09-N3nQGb6d38O_xgwN85Zo7MB7XWrvehe4YvbLgk3nztI_Q17NPt6er7PLz-cVpfZk1eS5FVvKGasqnyaucV5SDKUpW5gQ2UFGA3IIVhYWGF4LKRkhRThwtjSXcam34ETrZ9d7H8GswqVetS43xHjoThqQo45KIuXJClzt0spFSNFbdR9dCHBUlaratZttqb3sKvHvqHjaTnD3-T-8EyB3w23kz_qdO1R-v6ufl2S7rUm8e91mIP1VR8lKob9fnanXzXazW67WS_A8qwZtu</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1239057274</pqid></control><display><type>article</type><title>Antimicrobial and Antifouling Hydrogels Formed In Situ from Polycarbonate and Poly(ethylene glycol) via Michael Addition</title><source>Wiley Online Library</source><creator>Liu, Shao Qiong ; Yang, Chuan ; Huang, Yuan ; Ding, Xin ; Li, Yan ; Fan, Wei Min ; Hedrick, James L. ; Yang, Yi-Yan</creator><creatorcontrib>Liu, Shao Qiong ; Yang, Chuan ; Huang, Yuan ; Ding, Xin ; Li, Yan ; Fan, Wei Min ; Hedrick, James L. ; Yang, Yi-Yan</creatorcontrib><description>A novel class of antimicrobial cationic polycarbonate/PEG hydrogels are designed and synthesized by Michael addition chemistry. These hydrogels demonstrate strong broad‐spectrum antimicrobial activities against various clinically isolated multidrug‐resistant microbes. Moreover, they exhibit nonfouling properties and prevent the substrate from microbial adhesion. These antimicrobial and antifouling gels are promising materials as catheter coatings and wound dressings to prevent infections.</description><identifier>ISSN: 0935-9648</identifier><identifier>EISSN: 1521-4095</identifier><identifier>DOI: 10.1002/adma.201202225</identifier><identifier>PMID: 23018988</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Anti-Bacterial Agents - chemical synthesis ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; antifouling ; Biofouling - prevention & control ; broad spectrum antimicrobial ; Candida albicans - drug effects ; cationic polycarbonates ; Dose-Response Relationship, Drug ; Escherichia coli - drug effects ; hydrogels ; Hydrogels - chemical synthesis ; Hydrogels - chemistry ; Hydrogels - pharmacology ; michael addition ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Structure ; Polycarboxylate Cement - chemical synthesis ; Polycarboxylate Cement - chemistry ; Polycarboxylate Cement - pharmacology ; Polyethylene Glycols - chemical synthesis ; Polyethylene Glycols - chemistry ; Polyethylene Glycols - pharmacology ; Staphylococcus aureus - drug effects ; Structure-Activity Relationship ; tunable mechanical properties</subject><ispartof>Advanced materials (Weinheim), 2012-12, Vol.24 (48), p.6484-6489</ispartof><rights>Copyright © 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4495-73c1d131314843813ae672740aba81aa4faf56fac36519c595784317ef03fdde3</citedby><cites>FETCH-LOGICAL-c4495-73c1d131314843813ae672740aba81aa4faf56fac36519c595784317ef03fdde3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadma.201202225$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadma.201202225$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23018988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Shao Qiong</creatorcontrib><creatorcontrib>Yang, Chuan</creatorcontrib><creatorcontrib>Huang, Yuan</creatorcontrib><creatorcontrib>Ding, Xin</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Fan, Wei Min</creatorcontrib><creatorcontrib>Hedrick, James L.</creatorcontrib><creatorcontrib>Yang, Yi-Yan</creatorcontrib><title>Antimicrobial and Antifouling Hydrogels Formed In Situ from Polycarbonate and Poly(ethylene glycol) via Michael Addition</title><title>Advanced materials (Weinheim)</title><addtitle>Adv. Mater</addtitle><description>A novel class of antimicrobial cationic polycarbonate/PEG hydrogels are designed and synthesized by Michael addition chemistry. These hydrogels demonstrate strong broad‐spectrum antimicrobial activities against various clinically isolated multidrug‐resistant microbes. Moreover, they exhibit nonfouling properties and prevent the substrate from microbial adhesion. These antimicrobial and antifouling gels are promising materials as catheter coatings and wound dressings to prevent infections.</description><subject>Anti-Bacterial Agents - chemical synthesis</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>antifouling</subject><subject>Biofouling - prevention & control</subject><subject>broad spectrum antimicrobial</subject><subject>Candida albicans - drug effects</subject><subject>cationic polycarbonates</subject><subject>Dose-Response Relationship, Drug</subject><subject>Escherichia coli - drug effects</subject><subject>hydrogels</subject><subject>Hydrogels - chemical synthesis</subject><subject>Hydrogels - chemistry</subject><subject>Hydrogels - pharmacology</subject><subject>michael addition</subject><subject>Microbial Sensitivity Tests</subject><subject>Models, Molecular</subject><subject>Molecular Structure</subject><subject>Polycarboxylate Cement - chemical synthesis</subject><subject>Polycarboxylate Cement - chemistry</subject><subject>Polycarboxylate Cement - pharmacology</subject><subject>Polyethylene Glycols - chemical synthesis</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polyethylene Glycols - pharmacology</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Structure-Activity Relationship</subject><subject>tunable mechanical properties</subject><issn>0935-9648</issn><issn>1521-4095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqFkE1v1DAQhi0EotuWK0fkYzlk8UecxMeo0G61bUFqEdys2djeGpy42Elp_j0JW1a9oTmMNPO87-FB6C0lS0oI-wC6hSUjlBHGmHiBFlQwmuVEipdoQSQXmSzy6gAdpvSDECILUrxGB4wTWsmqWqDHuutd65oYNg48hk7j-WLD4F23xatRx7A1PuGzEFuj8UWHb1w_YBtDi78EPzYQN6GD3vzNzpcT09-N3nQGb6d38O_xgwN85Zo7MB7XWrvehe4YvbLgk3nztI_Q17NPt6er7PLz-cVpfZk1eS5FVvKGasqnyaucV5SDKUpW5gQ2UFGA3IIVhYWGF4LKRkhRThwtjSXcam34ETrZ9d7H8GswqVetS43xHjoThqQo45KIuXJClzt0spFSNFbdR9dCHBUlaratZttqb3sKvHvqHjaTnD3-T-8EyB3w23kz_qdO1R-v6ufl2S7rUm8e91mIP1VR8lKob9fnanXzXazW67WS_A8qwZtu</recordid><startdate>20121218</startdate><enddate>20121218</enddate><creator>Liu, Shao Qiong</creator><creator>Yang, Chuan</creator><creator>Huang, Yuan</creator><creator>Ding, Xin</creator><creator>Li, Yan</creator><creator>Fan, Wei Min</creator><creator>Hedrick, James L.</creator><creator>Yang, Yi-Yan</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121218</creationdate><title>Antimicrobial and Antifouling Hydrogels Formed In Situ from Polycarbonate and Poly(ethylene glycol) via Michael Addition</title><author>Liu, Shao Qiong ; Yang, Chuan ; Huang, Yuan ; Ding, Xin ; Li, Yan ; Fan, Wei Min ; Hedrick, James L. ; Yang, Yi-Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4495-73c1d131314843813ae672740aba81aa4faf56fac36519c595784317ef03fdde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Anti-Bacterial Agents - chemical synthesis</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>antifouling</topic><topic>Biofouling - prevention & control</topic><topic>broad spectrum antimicrobial</topic><topic>Candida albicans - drug effects</topic><topic>cationic polycarbonates</topic><topic>Dose-Response Relationship, Drug</topic><topic>Escherichia coli - drug effects</topic><topic>hydrogels</topic><topic>Hydrogels - chemical synthesis</topic><topic>Hydrogels - chemistry</topic><topic>Hydrogels - pharmacology</topic><topic>michael addition</topic><topic>Microbial Sensitivity Tests</topic><topic>Models, Molecular</topic><topic>Molecular Structure</topic><topic>Polycarboxylate Cement - chemical synthesis</topic><topic>Polycarboxylate Cement - chemistry</topic><topic>Polycarboxylate Cement - pharmacology</topic><topic>Polyethylene Glycols - chemical synthesis</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polyethylene Glycols - pharmacology</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Structure-Activity Relationship</topic><topic>tunable mechanical properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Shao Qiong</creatorcontrib><creatorcontrib>Yang, Chuan</creatorcontrib><creatorcontrib>Huang, Yuan</creatorcontrib><creatorcontrib>Ding, Xin</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Fan, Wei Min</creatorcontrib><creatorcontrib>Hedrick, James L.</creatorcontrib><creatorcontrib>Yang, Yi-Yan</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Advanced materials (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Shao Qiong</au><au>Yang, Chuan</au><au>Huang, Yuan</au><au>Ding, Xin</au><au>Li, Yan</au><au>Fan, Wei Min</au><au>Hedrick, James L.</au><au>Yang, Yi-Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimicrobial and Antifouling Hydrogels Formed In Situ from Polycarbonate and Poly(ethylene glycol) via Michael Addition</atitle><jtitle>Advanced materials (Weinheim)</jtitle><addtitle>Adv. Mater</addtitle><date>2012-12-18</date><risdate>2012</risdate><volume>24</volume><issue>48</issue><spage>6484</spage><epage>6489</epage><pages>6484-6489</pages><issn>0935-9648</issn><eissn>1521-4095</eissn><notes>istex:55D58E4FC2E326EE8187059F7C5E02B0F0D25F86</notes><notes>ArticleID:ADMA201202225</notes><notes>ark:/67375/WNG-HSX5HKKK-9</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>A novel class of antimicrobial cationic polycarbonate/PEG hydrogels are designed and synthesized by Michael addition chemistry. These hydrogels demonstrate strong broad‐spectrum antimicrobial activities against various clinically isolated multidrug‐resistant microbes. Moreover, they exhibit nonfouling properties and prevent the substrate from microbial adhesion. These antimicrobial and antifouling gels are promising materials as catheter coatings and wound dressings to prevent infections.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>23018988</pmid><doi>10.1002/adma.201202225</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0935-9648 |
| ispartof | Advanced materials (Weinheim), 2012-12, Vol.24 (48), p.6484-6489 |
| issn | 0935-9648 1521-4095 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1239057274 |
| source | Wiley Online Library |
| subjects | Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology antifouling Biofouling - prevention & control broad spectrum antimicrobial Candida albicans - drug effects cationic polycarbonates Dose-Response Relationship, Drug Escherichia coli - drug effects hydrogels Hydrogels - chemical synthesis Hydrogels - chemistry Hydrogels - pharmacology michael addition Microbial Sensitivity Tests Models, Molecular Molecular Structure Polycarboxylate Cement - chemical synthesis Polycarboxylate Cement - chemistry Polycarboxylate Cement - pharmacology Polyethylene Glycols - chemical synthesis Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacology Staphylococcus aureus - drug effects Structure-Activity Relationship tunable mechanical properties |
| title | Antimicrobial and Antifouling Hydrogels Formed In Situ from Polycarbonate and Poly(ethylene glycol) via Michael Addition |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T19%3A16%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antimicrobial%20and%20Antifouling%20Hydrogels%20Formed%20In%20Situ%20from%20Polycarbonate%20and%20Poly(ethylene%20glycol)%20via%20Michael%20Addition&rft.jtitle=Advanced%20materials%20(Weinheim)&rft.au=Liu,%20Shao%20Qiong&rft.date=2012-12-18&rft.volume=24&rft.issue=48&rft.spage=6484&rft.epage=6489&rft.pages=6484-6489&rft.issn=0935-9648&rft.eissn=1521-4095&rft_id=info:doi/10.1002/adma.201202225&rft_dat=%3Cproquest_cross%3E1239057274%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4495-73c1d131314843813ae672740aba81aa4faf56fac36519c595784317ef03fdde3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1239057274&rft_id=info:pmid/23018988&rfr_iscdi=true |