Antimicrobial and Antifouling Hydrogels Formed In Situ from Polycarbonate and Poly(ethylene glycol) via Michael Addition

A novel class of antimicrobial cationic polycarbonate/PEG hydrogels are designed and synthesized by Michael addition chemistry. These hydrogels demonstrate strong broad‐spectrum antimicrobial activities against various clinically isolated multidrug‐resistant microbes. Moreover, they exhibit nonfouli...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2012-12, Vol.24 (48), p.6484-6489
Main Authors: Liu, Shao Qiong, Yang, Chuan, Huang, Yuan, Ding, Xin, Li, Yan, Fan, Wei Min, Hedrick, James L., Yang, Yi-Yan
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
antifouling
Biofouling - prevention & control
broad spectrum antimicrobial
Candida albicans - drug effects
cationic polycarbonates
Dose-Response Relationship, Drug
Escherichia coli - drug effects
hydrogels
Hydrogels - chemical synthesis
Hydrogels - chemistry
Hydrogels - pharmacology
michael addition
Microbial Sensitivity Tests
Models, Molecular
Molecular Structure
Polycarboxylate Cement - chemical synthesis
Polycarboxylate Cement - chemistry
Polycarboxylate Cement - pharmacology
Polyethylene Glycols - chemical synthesis
Polyethylene Glycols - chemistry
Polyethylene Glycols - pharmacology
Staphylococcus aureus - drug effects
Structure-Activity Relationship
tunable mechanical properties
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Summary:A novel class of antimicrobial cationic polycarbonate/PEG hydrogels are designed and synthesized by Michael addition chemistry. These hydrogels demonstrate strong broad‐spectrum antimicrobial activities against various clinically isolated multidrug‐resistant microbes. Moreover, they exhibit nonfouling properties and prevent the substrate from microbial adhesion. These antimicrobial and antifouling gels are promising materials as catheter coatings and wound dressings to prevent infections.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201202225