Sleep disorders in Machado–Joseph disease: A dopamine transporter imaging study

Abstract Objectives Sleep disorders, especially restless legs syndrome (RLS) and rapid eye movement sleep behavior disorder (RBD), are common in spinocerebellar ataxia type 3 or Machado–Joseph disease (MJD), and a possible underlying dopaminergic dysfunction is implicated. This study assessed the re...

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Bibliographic Details
Published in:Journal of the neurological sciences 2013-01, Vol.324 (1), p.90-93
Main Authors: Pedroso, José Luiz, Braga-Neto, Pedro, Felício, André C, Minett, Thais, Yamaguchi, Elton, Prado, Lucila Bizari Fernandes do, Carvalho, Luciane Bizari C, Dutra, Lívia Almeida, Hoexter, Marcelo Queiroz, da Rocha, Antônio José, Bressan, Rodrigo A, Prado, Gilmar Fernandes do, Barsottini, Orlando Graziani Povoas
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dopamine Plasma Membrane Transport Proteins - genetics
Dopamine Plasma Membrane Transport Proteins - metabolism
Dopamine transporter
Female
Humans
Machado-Joseph Disease - complications
Machado-Joseph Disease - diagnostic imaging
Machado-Joseph Disease - genetics
Machado–Joseph disease
Male
Medical sciences
Middle Aged
Neurology
Nocturnal Myoclonus Syndrome - etiology
Organotechnetium Compounds
Polysomnography
Repetitive Sequences, Nucleic Acid
Restless Legs Syndrome - etiology
Sleep disorders
Sleep Wake Disorders - diagnostic imaging
Sleep Wake Disorders - etiology
Sleep Wake Disorders - genetics
Spinocerebellar ataxia type 3
Tomography, Emission-Computed, Single-Photon
Tropanes
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Summary:Abstract Objectives Sleep disorders, especially restless legs syndrome (RLS) and rapid eye movement sleep behavior disorder (RBD), are common in spinocerebellar ataxia type 3 or Machado–Joseph disease (MJD), and a possible underlying dopaminergic dysfunction is implicated. This study assessed the relationship between sleep disorders in MJD and dopamine transporter (DAT) densities. Patients and methods Twenty-two patients with MJD and twenty healthy subjects were enrolled in this study. MJD patients underwent clinical sleep evaluation and polysomnography. SPECT with [99m Tc]-TRODAT-1, was performed in all subjects. Results DAT densities were significantly reduced in MJD group when compared to controls. No significant correlation was found between DAT densities and RLS or RBD in MJD. Conclusion Our study failed to demonstrate a clear correlation between sleep disorders and DAT densities in MJD patients, hence suggesting that extrastriatal and non-presynaptic dopamine pathways could be implicated in MJD-related sleep disorders.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2012.10.008