A Novel Amine Receptor Based on the Binol Scaffold Functions as a Highly Effective Chiral Shift Reagent for Carboxylic Acids

A “smart” receptor has been newly synthesized. NMR studies demonstrated that the receptor functions as a chiral shift reagent that is highly effective for determining the enantiomeric purity of a series of carboxylic acids, particularly those that have an α-oxygen atom.

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Bibliographic Details
Published in:Organic letters 2012-12, Vol.14 (23), p.5813-5815
Main Authors: Ma, Qingzhu, Ma, Minshan, Tian, Hongying, Ye, Xiaoxia, Xiao, Hongping, Chen, Lian-hui, Lei, Xinxiang
Format: Article
Language:English
Subjects:
Carboxylic Acids - chemistry
Indicators and Reagents
Magnetic Resonance Spectroscopy
Molecular Structure
Naphthols - chemistry
Oxygen - chemistry
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Description
Summary:A “smart” receptor has been newly synthesized. NMR studies demonstrated that the receptor functions as a chiral shift reagent that is highly effective for determining the enantiomeric purity of a series of carboxylic acids, particularly those that have an α-oxygen atom.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol3027686