Mortality and morbidity of hepatectomy, radiofrequency ablation, and embolization for hepatocellular carcinoma: a national survey of 54,145 patients

Background Reported mortalities and morbidities of therapeutic procedures for liver tumors vary between studies, because of different designs and small sample sizes. We investigated the mortalities and complication rates for hepatectomy, radiofrequency ablation (RFA), and trans-catheter arterial emb...

Full description

Saved in:
Bibliographic Details
Published in:Journal of gastroenterology 2012-10, Vol.47 (10), p.1125-1133
Main Authors: Sato, Masaya, Tateishi, Ryosuke, Yasunaga, Hideo, Horiguchi, Hiromasa, Yoshida, Haruhiko, Matsuda, Shinya, Koike, Kazuhiko
Format: Article
Language:English
Subjects:
Abdominal Surgery
Ablation (Surgery)
Aged
Biliary Tract
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - surgery
Carcinoma, Hepatocellular - therapy
Catheter Ablation - adverse effects
Catheter Ablation - methods
Colorectal Surgery
Comorbidity
Embolization, Therapeutic - adverse effects
Embolization, Therapeutic - methods
Female
Gastroenterology
Health aspects
Hepatectomy - adverse effects
Hepatectomy - methods
Hepatology
Hepatoma
Hospital Mortality
Humans
Japan - epidemiology
Liver
Liver Neoplasms - mortality
Liver Neoplasms - surgery
Liver Neoplasms - therapy
Male
Medical colleges
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Morbidity
Mortality
Original Article—Liver
Pancreas
Postoperative Complications - epidemiology
Surgical Oncology
Surveys
Survival Rate
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Reported mortalities and morbidities of therapeutic procedures for liver tumors vary between studies, because of different designs and small sample sizes. We investigated the mortalities and complication rates for hepatectomy, radiofrequency ablation (RFA), and trans-catheter arterial embolization (TAE) for hepatocellular carcinoma (HCC) in a large sample, using a nationwide Japanese database (the Diagnosis Procedure Combination database). Methods Data from the Diagnosis Procedure Combination database were analyzed for July 1 to December 31, 2007 and the same period in 2008. We identified 54,145 patients with HCC who underwent hepatectomy ( n  = 5,270), RFA ( n  = 11,688), or TAE ( n  = 37,187). In-hospital mortality and morbidity were analyzed for each procedure. The relationships between mortality and factors including patient characteristics and procedural backgrounds were assessed. Results In-hospital mortalities associated with hepatectomy, RFA, and TAE were 2.6 % [95 % confidence interval (CI) 2.2–3.1], 0.3 % (0.2–0.4), and 1.0 % (0.9–1.1), and post-procedural complication rates were 14.5 % (13.5–15.5), 4.5 % (4.2–4.9), and 4.5 % (4.3–4.7), respectively. Increased mortality following hepatectomy was significantly associated with older age, extended lobectomy (vs. partial hepatectomy; odds ratio [OR] 3.80, p  
ISSN:0944-1174
1435-5922
DOI:10.1007/s00535-012-0569-0