Magnetic resonance imaging of dissolved hyperpolarized super(129Xe using a membrane-based continuous flow system)

A technique for continuous production of solutions containing hyperpolarized super(129Xe is explored for MRI applications. The method is based on hollow fiber membranes which inhibit the formation of foams and bubbles. A systematic analysis of various carrier agents for hyperpolarized ) super(1)29Xe...

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Bibliographic Details
Published in:Journal of magnetic resonance (1997) 2009-11, Vol.201 (1), p.93-99
Main Authors: Amor, N, Zaenker, P P, Bluemler, P, Meise, F M, Schreiber, L M, Scholz, A, Schmiedeskamp, J, Spiess, H W, Muennemann, K
Format: Article
Language:English
Subjects:
Carriers
Contrast agents
Dissolution
Foams
Imaging
Lungs
Magnetic resonance
Magnetic resonance imaging
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Summary:A technique for continuous production of solutions containing hyperpolarized super(129Xe is explored for MRI applications. The method is based on hollow fiber membranes which inhibit the formation of foams and bubbles. A systematic analysis of various carrier agents for hyperpolarized ) super(1)29Xe has been carried out, which are applicable as contrast agents for in vivo MRI. The image quality of different hyperpolarized Xe solutions is compared and MRI results obtained in a clinical as well as in a nonclinical MRI setting are provided. Moreover, we demonstrate the application of super(129Xe contrast agents produced with our dissolution method for lung MRI by imaging hyperpolarized ) super(1)29Xe that has been both dissolved in and outgassed from a carrier liquid in a lung phantom, illustrating its potential for the measurement of lung perfusion and ventilation.
ISSN:1090-7807
DOI:10.1016/j.jmr.2009.08.004