Changes in the Levels of Inhibitory and Excitatory Amino Acids in the Brain Structures of Female Rats with Cobalt Epileptogenic Focus during Different Phases of the Estrous Cycle

We studied changes in the levels of inhibitory and excitatory neurotransmitters in female rat brain structures during different phases of the estrous cycle in health and after creation of a cobalt epileptogenic focus at stage I of epileptogenic system development. The most pronounced shifts were fou...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2011-11, Vol.152 (1), p.47-49
Main Authors: Filatova, Yu. B., Voronina, T. A., Klodt, P. M., Kudrin, V. S., Nerobkova, L. N., Rider, F. K., Avakyan, G. N.
Format: Article
Language:eng ; rus
Subjects:
Animals
Animals, Outbred Strains
Aspartic Acid - metabolism
Biomedical and Life Sciences
Biomedicine
Biophysics and Biochemistry
Brain
Cell Biology
Cobalt
Cortex
Epilepsy - chemically induced
Epilepsy - metabolism
Estrous Cycle - metabolism
Estrus cycle
excitatory amino acids
Excitatory Amino Acids - metabolism
Female
GABA
gamma -Aminobutyric acid
gamma-Aminobutyric Acid - metabolism
Glutamate
Glycine
Glycine - metabolism
Hippocampus - metabolism
Hormones, Sex
Hypothalamus - metabolism
Internal Medicine
Laboratory Medicine
Menstruation
Motor Cortex - metabolism
Motor Cortex - pathology
Neurotransmitters
Pathology
Rats
Taurine - metabolism
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Summary:We studied changes in the levels of inhibitory and excitatory neurotransmitters in female rat brain structures during different phases of the estrous cycle in health and after creation of a cobalt epileptogenic focus at stage I of epileptogenic system development. The most pronounced shifts were found in the contralateral cortex, where the levels of GABA and glycine decreased significantly during the diestrus-2 phase (corresponding to menstruation), which attests to a convulsive threshold decrease during this period.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-011-1450-5