Comparison of the larynx-associated lymphoid tissue in the false vocal cords and subglottis in pediatric autopsies

The aim this work was to compare the distribution of cellular phenotypes of the LF in the FVC to the ones in the subglottic region in pediatric autopsy, relating this distribution to age and different causes of death. We analyzed 60 larynges of newborns and children autopsied in the period from 1993...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2012-12, Vol.208 (12), p.699-704
Main Authors: Rossi e Silva, Renata Calciolari, Olegário, Janainna Grazielle Pacheco, Rezende e Silva Abate, Débora Tavares de, Salge, Ana Karina Marques, Peres, Luiz César, Corrêa, Rosana Rosa Miranda, Castro, Eumenia Costa da Cunha, Teixeira, Vicente de Paula Antunes
Format: Article
Language:English
Subjects:
Age Factors
Antigens, CD - metabolism
Autopsy
Biomarkers - metabolism
Cause of Death
Dendritic Cells, Follicular - cytology
Dendritic Cells, Follicular - metabolism
False vocal cords
Female
Humans
Immunohistochemistry
Infant
Infant, Newborn
Lymphoid follicle
Lymphoid Tissue - anatomy & histology
Lymphoid Tissue - metabolism
Macrophages - cytology
Macrophages - metabolism
Male
Pediatric autopsy
Respiratory Tract Infections - immunology
Respiratory Tract Infections - mortality
Respiratory Tract Infections - pathology
T-Lymphocytes - cytology
T-Lymphocytes - metabolism
Vocal Cords - anatomy & histology
Vocal Cords - metabolism
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Summary:The aim this work was to compare the distribution of cellular phenotypes of the LF in the FVC to the ones in the subglottic region in pediatric autopsy, relating this distribution to age and different causes of death. We analyzed 60 larynges of newborns and children autopsied in the period from 1993 to 2003. The fragments were prepared in order to perform histochemical and immunohistochemical techniques. The morphological analysis showed cases that presented LF only in FVC (35%), LF only in the subglottic region (20%), lack of LF in FVC (30%) and lymphoid aggregates, which did not characterize an LF (15%). The cases of LF in the subglottic region were significantly younger compared to the ones that presented LF in the FVC (p=0.017). The LF in the subglottic region was bigger than the LF in the FVC (p=0.020). There was no significant difference between the cause of death and cellular phenotype for both FVC and the subglottic region. In conclusion, the cells that make up the LF in the FVC in newborns and children younger than one year have functional characteristics similar to LF cells in the subglottic region, suggesting that there are similarities with LALT.
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2012.08.003