Superficial x-ray in the treatment of basal and squamous cell carcinomas: A viable option in select patients

Background Effective nonsurgical modalities are limited in the treatment of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Objective We sought to evaluate the efficacy and viability of superficial x-ray therapy in the treatment of BCC and SCC in an outpatient setting. Methods A retros...

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Published in:Journal of the American Academy of Dermatology 2012-12, Vol.67 (6), p.1235-1241
Main Authors: Cognetta, Armand B., MD, Howard, Brett M., BA, Heaton, Henry P., BA, Stoddard, Earl R., MD, Hong, Hyokyoung Grace, PhD, Green, W. Harris, MD
Format: Article
Language:English
Subjects:
Aged
basal cell carcinoma
Biological and medical sciences
Carcinoma, Basal Cell - radiotherapy
Carcinoma, Squamous Cell - radiotherapy
Dermatology
Female
Humans
Male
Medical sciences
Patient Selection
photon therapy
radiation
radiation therapy
Retrospective Studies
skin cancer
Skin Neoplasms - radiotherapy
squamous cell carcinoma
superficial radiation therapy
superficial x-ray therapy
Tumors of the skin and soft tissue. Premalignant lesions
x-ray
x-ray therapy
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Summary:Background Effective nonsurgical modalities are limited in the treatment of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Objective We sought to evaluate the efficacy and viability of superficial x-ray therapy in the treatment of BCC and SCC in an outpatient setting. Methods A retrospective analysis was performed on 1715 histologically confirmed primary cutaneous BCC and SCC treated with superficial x-ray therapy at Dermatology Associates of Tallahassee in Florida between 2000 and 2010. Results Of the 1715 tumors reviewed during this period, 712 were histologically proven BCC (631 nodular and 81 superficial), 994 were SCC (861 SCC in situ and 133 invasive SCC), and 9 displayed distinct features of both BCC and SCC in the same biopsy specimen. Kaplan-Meier estimates (with 95% confidence intervals) of cumulative recurrence rates of all tumors at 2 and 5 years were 1.9% (1%-2.7%) and 5.0% (3.2%-6.7%), respectively; of BCC at 2 and 5 years were 2% (0.8%-3.3%) and 4.2% (1.9%-6.4%), respectively; and of all SCC at 2 and 5 years were 1.8% (0.8%-2.8%) and 5.8% (2.9%-8.7%), respectively. Tumors on male patients and those with a diameter greater than 2 cm were associated with a statistically significant increase in recurrence likelihood. Limitations This study represents only patients treated in 1 dermatology office in North Florida and may not be representative of the general patient population. Conclusions Superficial x-ray therapy remains a viable nonsurgical option for the treatment of primary BCC and SCC in patients where surgical intervention is declined, unadvisable, or potentially associated with significant cosmetic or functional limitations.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2012.06.001