Intralesional Cidofovir in the Treatment of Cutaneous Warts in a Renal Transplant Patient

Background: Cutaneous warts are often recalcitrant to conventional therapy in immunocompromised patients. Cidofovir is a potent antiviral agent shown to have a broad spectrum of action against DNA virus, including human papillomavirus. Objective: To determine the efficacy of intralesional cidofovir...

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Bibliographic Details
Published in:Journal of cutaneous medicine and surgery 2012-11, Vol.16 (6), p.462-464
Main Authors: Blouin, Marie-Michèle, Cloutier, Richard, Noël, Réal
Format: Article
Language:English
Subjects:
Adult
Antiviral Agents - administration & dosage
Antiviral Agents - therapeutic use
Biological and medical sciences
Cytosine - administration & dosage
Cytosine - analogs & derivatives
Cytosine - therapeutic use
Dermatology
Hand Dermatoses - drug therapy
Hand Dermatoses - virology
Human viral diseases
Humans
Immunocompromised Host
Infectious diseases
Injections, Intralesional
Kidney Transplantation - immunology
Male
Medical research
Medical sciences
Medical treatment
Organophosphonates - administration & dosage
Organophosphonates - therapeutic use
Patients
Viral diseases
Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
Warts
Warts - drug therapy
Warts - virology
Young Adult
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Summary:Background: Cutaneous warts are often recalcitrant to conventional therapy in immunocompromised patients. Cidofovir is a potent antiviral agent shown to have a broad spectrum of action against DNA virus, including human papillomavirus. Objective: To determine the efficacy of intralesional cidofovir in the treatment of florid warts in an immunocompromised renal transplant patient. Method: The patient received seven injections of intralesional cidofovir at 4 week intervals in his numerous palmar warts. Conclusion: Based on our results, intralesional cidofovir is a promising therapeutic modality in the treatment of cutaneous warts in the renal transplant population. Contexte: Les verrues cutanées se montrent souvent réfractaires au traitement habituel chez les immunodéficients. Le cidofovir est un antiviral puissant, doté d'un large spectre d'action contre les virus à ADN, y compris contre le papillomavirus humain. Objectif: L'étude visait à déterminer l'efficacité du cidofovir intralésionnel dans le traitement de verrues florides chez un patient immunodéprimé, ayant subi une transplantation rénale. Méthode: Le patient a reçu sept injections de cidofovir intralésionnel, à 4 semaines d'intervalle, dans les nombreuses verrues palmaires. Conclusion: D'après les résultats obtenus, le cidofovir intralésionnel serait porteur d'avenir dans le traitement des verrues cutanées chez les patients ayant subi une transplantation rénale.
ISSN:1203-4754
1615-7109
DOI:10.1177/120347541201600622