Anemia at 1 Year After Kidney Transplantation Has a Negative Long-term Impact on Graft and Patient Outcomes

Abstract Background Anemia, a common complication after kidney transplantation, has a controversial impact on graft or patient survivals or the appearance of cardiovascular disease. The present study investigated the incidence and risk factors for anemia in the first year after transplantation and i...

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Published in:Transplantation proceedings 2012-11, Vol.44 (9), p.2593-2595
Main Authors: Marcén, R, Galeano, C, Fernandez-Rodriguez, A, Jiménez, S, Teruel, J.L, Burgos, F.J, Quereda, C
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Anemia - blood
Anemia - drug therapy
Anemia - epidemiology
Anemia - mortality
Biomarkers - blood
Cardiovascular Diseases - epidemiology
Creatinine - blood
Cyclosporine - adverse effects
Female
Graft Survival
Hematinics - therapeutic use
Hemoglobins - metabolism
Humans
Immunosuppressive Agents - adverse effects
Incidence
Kaplan-Meier Estimate
Kidney Transplantation - adverse effects
Kidney Transplantation - mortality
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Proportional Hazards Models
Risk Factors
Serum Albumin - metabolism
Serum Albumin, Human
Spain - epidemiology
Surgery
Time Factors
Treatment Outcome
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Summary:Abstract Background Anemia, a common complication after kidney transplantation, has a controversial impact on graft or patient survivals or the appearance of cardiovascular disease. The present study investigated the incidence and risk factors for anemia in the first year after transplantation and its effects on graft and patient outcomes. Patients and Methods Among 389 patients transplanted between January 2000 and June 2008, the 331 with functioning grafts at 1 year were included in the study. The mean follow-up was 84 ± 31.8 months. Anemia was defined according to the World Health Organization as a hemoglobin < 13 g/dL in men and < 12 g/dL in women. Results The 88 patients (26.6%) with anemia included 21 (6.3%) who were receiving erythropoiesis stimulant agents. The predictive factors for anemia were: initial immunosuppression with cyclosporine (odds ratio [OR] 2.08, 95% confidence interval [CI] 1.25−3.47; P = .005), serum creatinine (mg/dL) at discharge (OR 1.7; CI 95% 1.26−2.15 P = .000), and 1-year serum albumin (g/dL; OR 0.21; CI 95% 0.10−0.71 P = .001). Donor age in years (OR 1.02; CI 95% 1.00−1.03, P = .054) was close to significance. Cox multivariate analysis showed 1-year hemoglobin (g/dL) to be associated with graft (hazard ratio [HR] 0.81, 95% CI 0.69−0.96, P = .003) and patient survivals after adjusting for other variables (HR 0.74; 95% CI 0-59-0.96, P = .023). But it was only a cardiovascular risk factor when serum creatinine was not included in the model. Conclusions Approximately one quarter of patients with functioning grafts show anemia at 1-year. Graft function, initial immunosuppression, serum albumin, and perhaps donor age were risk factors for anemia, which had a negative impact on graft and patient survival, and could be a risk factor for cardiovascular disease.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2012.09.033