Porphyromonas gingivalis infection at different gestation periods on fetus development and cytokines profile

Oral Diseases (2012) 18, 648–654 Aim:  Infective agents may affect pregnancy outcomes by deregulating homeostasis. Objectives:  The effects of Porphyromonas gingivalis infection before and at different gestation periods were evaluated. Materials and Methods:  Wistar rats infected via subcutaneous wi...

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Bibliographic Details
Published in:Oral diseases 2012-10, Vol.18 (7), p.648-654
Main Authors: Michelin, MCAN, Teixeira, SRL, Ando-Suguimoto, ES, Lucas, SRR, Mayer, MPA
Format: Article
Language:English
Subjects:
animal model
Animals
Bacteroidaceae Infections - blood
Cytokines
Dentistry
Dinoprostone - analysis
Dinoprostone - blood
DNA, Bacterial - analysis
Female
fetal and embrionary development
Fetal Development
Gestational Age
Interleukin-1beta - analysis
Interleukin-1beta - blood
Interleukin-6 - analysis
Interleukin-6 - blood
Maternal-Fetal Exchange
Placenta - chemistry
Placenta - microbiology
Porphyromonas gingivalis
Pregnancy
Pregnancy Complications, Infectious - blood
Pregnancy Complications, Infectious - microbiology
Pregnancy Outcome
Rats
Rats, Wistar
Tumor Necrosis Factor-alpha - analysis
Tumor Necrosis Factor-alpha - blood
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Summary:Oral Diseases (2012) 18, 648–654 Aim:  Infective agents may affect pregnancy outcomes by deregulating homeostasis. Objectives:  The effects of Porphyromonas gingivalis infection before and at different gestation periods were evaluated. Materials and Methods:  Wistar rats infected via subcutaneous with P. gingivalis W83, one week before mating (BM), days 1 (PR1) and 11 of gestation (PR11), and controls were evaluated, and samples were obtained at the end of gestation. P. gingivalis was detected by PCR. Cytokine was determined by ELISA. Results:  Infected rats had lower maternal gain of weight. Implantation was not observed in 2/12 BM rats. PR11 presented more fetal‐placental resorptions and lower placenta/fetus weight than controls. P. gingivalis was detected in placenta and fetus. IL‐6 and TNF‐α levels were higher in placenta and serum of infected groups, except for TNF‐α in placenta of PR1. IL‐1β levels were higher in placenta of PR11, but lower in serum and placenta of PR1. There were no differences in IL‐10 and PGE2 concentrations among the groups (P 
ISSN:1354-523X
1601-0825
DOI:10.1111/j.1601-0825.2012.01917.x