Benzimidazoles as benzamide replacements within cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists

We describe the design, synthesis, and evaluation of benzimidazoles as benzamide replacements within a series of trisubstituted cyclohexane CCR2 antagonists. We describe the design, synthesis, and evaluation of benzimidazoles as benzamide replacements within a series of trisubstituted cyclohexane CC...

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Bibliographic Details

Published in:	Bioorganic & medicinal chemistry letters 2012-10, Vol.22 (19), p.6181-6184
Main Authors:	Cherney, Robert J., Mo, Ruowei, Meyer, Dayton T., Pechulis, Anthony D., Guaciaro, Michael A., Lo, Yvonne C., Yang, Gengjie, Miller, Persymphonie B., Scherle, Peggy A., Zhao, Qihong, Cvijic, Mary Ellen, Barrish, Joel C., Decicco, Carl P., Carter, Percy H.
Format:	Article
Language:	eng
Subjects:	antagonists Benzimidazole benzimidazoles Benzimidazoles - chemical synthesis Benzimidazoles - chemistry Benzimidazoles - pharmacology beta chemokines Biological and medical sciences CCR2 CCR2 antagonist chemistry Chemokine antagonist Cyclohexanes - chemistry Dose-Response Relationship, Drug Drug Design GPCR Humans Indexing in process Medical sciences Microsomes - drug effects Molecular Structure Pharmacology. Drug treatments Receptors, CCR2 - antagonists & inhibitors Structure-Activity Relationship
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