ELA-DRA polymorphisms are not associated with Equine Arteritis Virus infection in horses from Argentina

Polymorphisms at Major Histocompatibility Complex (MHC) genes have been associated with resistance/susceptibility to infectious diseases in domestic animals. The aim of this investigation was to evaluate whether polymorphisms of the DRA gene the Equine Lymphocyte Antigen is associated with susceptib...

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Bibliographic Details
Published in:Research in veterinary science 2012-12, Vol.93 (3), p.1271-1273
Main Authors: Kalemkerian, P.B., Metz, G.E., Peral-Garcia, P., Echeverria, M.G., Giovambattista, G., Díaz, S.
Format: Article
Language:English
Subjects:
alleles
Animals
antigens
Argentina - epidemiology
Arteritis Virus, Equine
Arterivirus Infections - epidemiology
Arterivirus Infections - genetics
Arterivirus Infections - veterinary
Equine arteritis virus
Equine Lymphocyte Antigen
Equine Viral Arteritis
exons
gene frequency
Genetic susceptibility
Genotype
Horse Diseases - epidemiology
Horse Diseases - genetics
Horse Diseases - virology
Horses
infectious diseases
major histocompatibility complex
Major Histocompatibility Complex - genetics
Polymorphism
Polymorphism, Genetic
Veterinary medicine
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Summary:Polymorphisms at Major Histocompatibility Complex (MHC) genes have been associated with resistance/susceptibility to infectious diseases in domestic animals. The aim of this investigation was to evaluate whether polymorphisms of the DRA gene the Equine Lymphocyte Antigen is associated with susceptibility to Equine Arteritis Virus (EAV) infection in horses in Argentina. The equine DRA gene was screened for polymorphisms using Pyrosequencing® Technology which allowed the detection of three ELA-DRA exon 2 alleles. Neither allele frequencies nor genotypic differentiation exhibited any statistically significant (P-values=0.788 and 0.745) differences between the EAV-infected and no-infected horses. Fisher’s exact test and OR calculations did not show any significant association. As a consequence, no association could be established between the serological condition and ELA-DRA.
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2012.03.007