Inflammation linking EMT and cancer stem cells

Summary Similar to actors changing costumes during a performance, cancer cells undergo many rapid changes during the process of tumor metastasis, including epithelial–mesenchymal transition (EMT), acquisition of cancer stem cells (CSCs) properties, and mesenchymal–epithelial transition (MET). Such c...

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Bibliographic Details
Published in:Oral oncology 2012-11, Vol.48 (11), p.1068-1075
Main Authors: Zhou, Chenchen, Liu, Jeffrey, Tang, Yaling, Liang, Xinhua
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers, Tumor - biosynthesis
Cancer stem cells (CSCs)
Cell Transformation, Neoplastic - metabolism
Cell Transformation, Neoplastic - pathology
Cytokines - metabolism
Epithelial-Mesenchymal Transition - physiology
Epithelial–mesenchymal transition (EMT)
Hematology, Oncology and Palliative Medicine
Humans
Inflammation - metabolism
Inflammation - pathology
Inflammation microenvironment
Medical sciences
Neoplasm Invasiveness - pathology
Neoplasm Metastasis - pathology
Neoplastic Stem Cells - pathology
Otolaryngology
Otorhinolaryngology. Stomatology
Tumor Microenvironment
Tumors
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Summary:Summary Similar to actors changing costumes during a performance, cancer cells undergo many rapid changes during the process of tumor metastasis, including epithelial–mesenchymal transition (EMT), acquisition of cancer stem cells (CSCs) properties, and mesenchymal–epithelial transition (MET). Such changes allow the tumor to compete with the normal microenvironment to overcome anti-tumorigenic pressures. Then, once tissue homeostasis is lost, the altered microenvironment, like that accompanying inflammation, can itself become a potent tumor promoter. This review will discuss the changes that cancer cells undergo in converting from EMT to CSCs in an inflammation microenvironment, to understand the mechanisms behind invasion and metastasis and provide insights into prevention of metastasis.
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2012.06.005