Dietary Selenium Deficiency Partially Rescues Type 2 Diabetes―Like Phenotypes of Glutathione Peroxidase-1―Overexpressing Male Mice

This study was conducted to determine whether dietary Se deficiency precluded overproduction of glutathione peroxidase-1 (GPX1) activity in mice overexpressing (OE) this gene and thus rescued their type 2 diabetes-like phenotypes. A total of 20 male OE and wild-type (WT) mice were fed an Se-deficien...

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Bibliographic Details
Published in:The Journal of nutrition 2012-11, Vol.142 (11), p.1975-1982
Main Authors: XI YAN, PEPPER, Matthew P, VATAMANIUK, Marko Z, RONEKER, Carol A, LI LI, XIN GEN LEI
Format: Article
Language:English
Subjects:
Animal Feed
Animals
Biological and medical sciences
Blood Glucose - physiology
Diabetes Mellitus, Type 2 - metabolism
Diet - veterinary
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Enzymologic - physiology
Glutathione Peroxidase - genetics
Glutathione Peroxidase - metabolism
Glutathione Peroxidase GPX1
Insulin - blood
Insulin - metabolism
Islets of Langerhans - metabolism
Lipid Metabolism
Liver - metabolism
Male
Mice
Mice, Transgenic
Phenotype
Selenium - deficiency
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:This study was conducted to determine whether dietary Se deficiency precluded overproduction of glutathione peroxidase-1 (GPX1) activity in mice overexpressing (OE) this gene and thus rescued their type 2 diabetes-like phenotypes. A total of 20 male OE and wild-type (WT) mice were fed an Se-deficient (
ISSN:0022-3166
1541-6100
DOI:10.3945/jn.112.164764