The modulation of venlafaxine on cortical activation of language area in healthy subjects with fMRI study

Rationale Previous studies have shown that selective serotonin reuptake inhibitors, activators of the cortex, apparently improved language functional recovery after brain damage rather than simply affective disorders. Objective Our aim was to determine whether venlafaxine (an agonist of both norepin...

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Bibliographic Details
Published in:Psychopharmacologia 2012-10, Vol.223 (4), p.417-425
Main Authors: Xie, Qi, Liu, Yan, Li, Chun-Yong, Song, Xue-Zhu, Wang, Jun, Han, Li-Xin, Bai, Hong-Min
Format: Article
Language:English
Subjects:
Adult
Affective disorders
Age
Antidepressants
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Brain
Brain damage
Brain injury
Brain Mapping
Cerebral Cortex - drug effects
Cognition
Cognition & reasoning
Cortex
Cortex (frontal)
Cross-Over Studies
Cyclohexanols - pharmacology
Double-Blind Method
Functional magnetic resonance imaging
Humans
Language
Language Tests
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medical sciences
Neuropharmacology
Neurosciences
NMR
Norepinephrine
Nuclear magnetic resonance
Occipital lobe
Original Investigation
Pharmacology. Drug treatments
Pharmacology/Toxicology
Psychiatry
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Recovery of function
Serotonin
Serotonin uptake inhibitors
Serotonin Uptake Inhibitors - pharmacology
Time Factors
Venlafaxine
Venlafaxine Hydrochloride
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Summary:Rationale Previous studies have shown that selective serotonin reuptake inhibitors, activators of the cortex, apparently improved language functional recovery after brain damage rather than simply affective disorders. Objective Our aim was to determine whether venlafaxine (an agonist of both norepinephrine and 5-hydroxytryptamine) could modulate language cortex function. Methods A double-blind, crossover, randomized design was used to compare two 7-day treatment sessions with either venlafaxine (75 mg per day) or placebo. A functional magnetic resonance imaging experiment and two language function tests were performed on eight healthy males (mean age, 28.25 ± 3.15 years) at the end of each session, i.e., study entry, after venlafaxine, and after placebo (days 0, 7, and 18). Hyperactivation (venlafaxine minus placebo >0) or hypoactivation (placebo minus venlafaxine >0) by venlaxafine was assessed on the basis of the activation–baseline contrast. Results The naming score ( P  
ISSN:0033-3158
1432-2072
DOI:10.1007/s00213-012-2730-0