Does Antenatal Tobacco or Alcohol Exposure Influence a Child's Cerebral Palsy? A Population-Based Study

Abstract Antenatal tobacco and alcohol exposure are established risk factors for premature birth and an independent risk factor for cerebral palsy. Both exert adverse effects on fetal development. In children with cerebral palsy, whether antenatal exposure to tobacco or alcohol is associated with a...

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Bibliographic Details
Published in:Pediatric neurology 2012-11, Vol.47 (5), p.349-354
Main Authors: Kyriakopoulos, Paulina, BSc, Oskoui, Maryam, MDCM, Dagenais, Lynn, PT, Shevell, Michael I., MDCM
Format: Article
Language:English
Subjects:
Alcohol Drinking - adverse effects
Alcohol Drinking - epidemiology
Biological and medical sciences
Birth weight
Cerebral Palsy - diagnosis
Cerebral Palsy - epidemiology
Child
Children
Classification systems
Development
Ethanol
Female
Fetuses
Humans
Intrauterine exposure
Male
Medical sciences
Neurology
Paralysis
Pediatrics
Population studies
Population Surveillance - methods
Pregnancy
Prenatal Exposure Delayed Effects - diagnosis
Prenatal Exposure Delayed Effects - epidemiology
Quebec - epidemiology
Registries
Risk factors
Side effects
Smoking - adverse effects
Smoking - epidemiology
Tobacco
Tobacco Products - adverse effects
Vascular diseases and vascular malformations of the nervous system
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Summary:Abstract Antenatal tobacco and alcohol exposure are established risk factors for premature birth and an independent risk factor for cerebral palsy. Both exert adverse effects on fetal development. In children with cerebral palsy, whether antenatal exposure to tobacco or alcohol is associated with a difference in clinical profile remains unknown. The Quebec Cerebral Palsy Registry was used to compare neurologic subtypes, gross motor functional impairment, and comorbidities in children with cerebral palsy who were or were not prenatally exposed to alcohol or tobacco. Information on in utero exposure was available in 249 children with cerebral palsy born from 1999-2002, of whom 77 were exposed to alcohol and 62 to tobacco in utero. No association was evident between exposure to tobacco or alcohol during pregnancy and neurologic subtype, Gross Motor Function Classification System score, mean number of comorbidities experienced, or each of eight comorbidities explored. Adjusting for prematurity or low birth weight exerted no effect on these results. In utero exposure to tobacco or alcohol does not assist in predicting clinical profiles of cerebral palsy.
ISSN:0887-8994
1873-5150
DOI:10.1016/j.pediatrneurol.2012.08.004