Decreased plasma gelsolin is associated with 1-year outcome in patients with traumatic brain injury

Abstract Purpose Decreased plasma gelsolin level has been associated with 1-month mortality after traumatic brain injury (TBI). Thus, we investigated the ability of gelsolin to predict 1-year mortality and functional outcome in these patients. Methods One hundred fourteen healthy controls and 114 pa...

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Published in:Journal of critical care 2012-10, Vol.27 (5), p.527.e1-527.e6
Main Authors: Jin, Yong, MD, Li, Bo-You, MD, Qiu, Ling-Li, MD, Ling, Yuan-Ren, MD, Bai, Zhi-Qiang, MD
Format: Article
Language:English
Subjects:
1-year outcome
Adult
Age Factors
Aged
Biomarkers
Brain Injuries - blood
Brain Injuries - diagnosis
Brain Injuries - mortality
Critical Care
Female
Gelsolin
Gelsolin - blood
Glasgow Outcome Scale
Head injuries
Hemorrhage
Humans
Hyperglycemia
Male
Middle Aged
Mortality
Plasma
Prognosis
Proteins
Sensitivity and Specificity
Sex Factors
Traumatic brain injury
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Summary:Abstract Purpose Decreased plasma gelsolin level has been associated with 1-month mortality after traumatic brain injury (TBI). Thus, we investigated the ability of gelsolin to predict 1-year mortality and functional outcome in these patients. Methods One hundred fourteen healthy controls and 114 patients with acute severe TBI were included in this study. Plasma gelsolin concentration on admission was measured by ELISA. Results Fifty-five patients (48.2%) had unfavorable outcome (Glasgow Outcome Scale score of 1-3) and 38 patients (33.3%) died in 1 year after TBI. Upon admission, plasma gelsolin level in patients was substantially lower than that in healthy controls. A multivariate analysis selected plasma gelsolin level as an independent predictor for 1-year unfavorable outcome and mortality of patients. A receiver operating characteristic curve analysis showed plasma gelsolin level predicted 1-year unfavorable outcome and mortality statistically significantly. The predictive value of the gelsolin concentration was thus similar to that of Glasgow Coma Scale (GCS) score. In a combined logistic-regression model, gelsolin did not statistically significantly improve the area under curve of GCS score. Conclusions Plasma gelsolin level is a useful, complementary tool to predict functional outcome and mortality 1 year after TBI.
ISSN:0883-9441
1557-8615
DOI:10.1016/j.jcrc.2012.01.002