The effect of a calcium phosphate mouth rinse on (chemo) radiation induced oral mucositis in head and neck cancer patients: a prospective study

Objectives Promising results of a calcium phosphate (CP) mouth rinse on reduced severity of oral mucositis have been reported. The aim of this study was to determine the effect of a CP mouth rinse on the frequency, duration and severity of (chemo) radiation induced oral mucositis in patients with he...

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Bibliographic Details
Published in:International journal of dental hygiene 2012-08, Vol.10 (3), p.175-180
Main Authors: Stokman, MA, Burlage, FR, Spijkervet, FKL
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
calcium phosphate rinse
Calcium phosphates
Calcium Phosphates - chemistry
Calcium Phosphates - therapeutic use
chemoradiation
Dental care
Dental health
Dentistry
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Female
head and neck cancer
Head and Neck Neoplasms - radiotherapy
Humans
Male
Medical sciences
Middle Aged
Mouth
Mouthwashes - chemistry
Mouthwashes - therapeutic use
mucositis
Non tumoral diseases
oral care
Oral hygiene
Otorhinolaryngology (head neck, general aspects and miscellaneous)
Otorhinolaryngology. Stomatology
Prospective Studies
radiotherapy
Radiotherapy - adverse effects
Stomatitis - drug therapy
Stomatitis - etiology
Tumors
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Summary:Objectives Promising results of a calcium phosphate (CP) mouth rinse on reduced severity of oral mucositis have been reported. The aim of this study was to determine the effect of a CP mouth rinse on the frequency, duration and severity of (chemo) radiation induced oral mucositis in patients with head–neck cancer. Material and method patients with oral malignancies, treated with (chemo) radiotherapy, were included. Patients rinsed four times a day with a CP mouth rinse. Patients not willing to rinse with the CP mouth rinse served as control. Mucositis was scored according to the WHO score at baseline and twice a week during the full course of (chemo) radiotherapy. Patient's self‐reported mouth‐throat soreness (MTS) was evaluated at the same time interval using a diary in the CP mouth rinse group. The outcomes on MTS were compared with a historical control group. Results Fifty‐two patients were analysed: 25 CP mouth rinse group, 11 control group and 16 historical group. There was no significant difference between the CP group and control group on development and severity of oral mucositis. No significant difference was found for subjective outcomes on MTS between the CP group and the historical group. Conclusions The CP mouth rinse seems to have no influence on the frequency, duration and severity of oral mucositis during (chemo) radiation in patients with head and neck cancer. A trend to develop less MTS for drinking and eating was found when applying the CP mouth rinse.
ISSN:1601-5029
1601-5037
DOI:10.1111/j.1601-5037.2012.00574.x