Head Space Mass Spectrometric Analysis for Volatiles in Biological Specimens

A simple and rapid head space mess spectrometric screening technique for volatiles in blood and post-mortem tissues is described. Mass spectral data on specimens from acute toxicities due to fluorocarbons (Freons), methane, diethylether, and toluene are presented. The presence of the volatile anesth...

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Bibliographic Details
Published in:Journal of analytical toxicology 1977-09, Vol.1 (5), p.195-199
Main Authors: Urich, Raoul W., Bowerman, David L., Wittenberg, Peter H., Pierce, Alson F., Schisler, Dianne K., Levisky, Joseph A., Pflug, J. Lloyd
Format: Article
Language:English
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Summary:A simple and rapid head space mess spectrometric screening technique for volatiles in blood and post-mortem tissues is described. Mass spectral data on specimens from acute toxicities due to fluorocarbons (Freons), methane, diethylether, and toluene are presented. The presence of the volatile anesthetic agents, nitrous oxide, halothane (Fluothane) and enflurane (Ethrane), in the blood of surgical patients is demonstrated. Xylene, toluene, CCI4, CHCI3, acetonitrile, and methylethylketone in blood-enriched specimens also exhibit characteristic mass spectra. The detection limit for this technique is approximately 1µg/ml.
ISSN:0146-4760
1945-2403
DOI:10.1093/jat/1.5.195