Phencyclidine: Studies of Tissue Concentrations in the Rat, Monkey, and Man

Phencyclidine concentrations were studied in the tissues of rats, monkeys, and man. Following intraperitoneal injection of phencyclidine into ten Sprague-Dawley rats, the mean concentration of the drug in liver (517 µ g/g) was significantly higher (pliver>serum>adipose tissue. In seven phencyc...

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Bibliographic Details
Published in:Journal of analytical toxicology 1979-11, Vol.3 (6), p.235-237
Main Authors: Bailey, David N., Shaw, Richard F., Robinson, Phillip T., Guba, John J.
Format: Article
Language:English
Subjects:
Blood levels
Brain
Cerebrum
Drugs
Intravenous administration
Liver
Lung
Macaca mulatta
Macaca nemestrina
Phencyclidine
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Summary:Phencyclidine concentrations were studied in the tissues of rats, monkeys, and man. Following intraperitoneal injection of phencyclidine into ten Sprague-Dawley rats, the mean concentration of the drug in liver (517 µ g/g) was significantly higher (pliver>serum>adipose tissue. In seven phencyclidine-related deaths in humans the concentration in blood showed significant correlation with that in liver (r = 0.916, p
ISSN:0146-4760
1945-2403
DOI:10.1093/jat/3.6.235