Radioimmunoassay of Hydromorphone in Plasma

A radioimmunoassay for hydromorphone in plasma has been developed from a commercially available RIA kit. The method is capable of detecting drugs in the 10 – 40 ng/ml range using 0.1 ml of sample. Accuracy of the procedure using spiked human plasma samples Is + 20%. Analysis of human plasma samples...

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Bibliographic Details
Published in:Journal of analytical toxicology 1977-03, Vol.1 (2), p.70-72
Main Authors: Honigberg, I.L., Stewart, J.T., Brown, W.J., Jun, H.W., Needham, T.E., Vallner, J.J.
Format: Article
Language:English
Subjects:
Drugs
Radioimmunoassay
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Summary:A radioimmunoassay for hydromorphone in plasma has been developed from a commercially available RIA kit. The method is capable of detecting drugs in the 10 – 40 ng/ml range using 0.1 ml of sample. Accuracy of the procedure using spiked human plasma samples Is + 20%. Analysis of human plasma samples from subjects administered hydromorphone in a clinical setting indicated that the method will detect therapeutic levels of drug.
ISSN:0146-4760
1945-2403
DOI:10.1093/jat/1.2.70