Surrogate tissue telomere length and cancer risk: Shorter or Longer?

Abstract Telomeres play a critical role in chromosome stability. Telomere length (TL) shortening is a risk factor for cancers. Measuring TL in surrogate tissues that can be easily collected may provide a potential tool for early detection of cancers. A number of studies on surrogate tissue TL and ca...

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Bibliographic Details
Published in:Cancer letters 2012-06, Vol.319 (2), p.130-135
Main Authors: Hou, Lifang, Zhang, Xiao, Gawron, Andrew J, Liu, Jie
Format: Article
Language:English
Subjects:
Breast cancer
Cancer
Chromosomes
Data processing
Hematology, Oncology and Palliative Medicine
Hormone replacement therapy
Humans
Medical research
neoplasms
Neoplasms - genetics
Reviews
risk
Risk Factors
Rodents
Specimen Handling
Telomere Homeostasis
Telomere Shortening
Telomeres
Tissues
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Summary:Abstract Telomeres play a critical role in chromosome stability. Telomere length (TL) shortening is a risk factor for cancers. Measuring TL in surrogate tissues that can be easily collected may provide a potential tool for early detection of cancers. A number of studies on surrogate tissue TL and cancer risks have been conducted and results are inconsistent, including positive, negative, or null associations. In this article, we reviewed the published data on surrogate tissue TL in relation to cancer risks, discussed the possible reasons for the differences in the results and future directions and challenges for this line of research.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2012.01.028