Tilorone Determination in a Corneal Biopsy

Tilorone, an anti-tumor agent presently under investigation, appeared to be associated with corneal opacities. Attempts to measure levels of this drug in tissues from the eye required techniques of hiqh sensitivity. Applications of ultraviolet spectrophotometry, thin-layer chromatography (TLC), high...

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Bibliographic Details
Published in:Journal of analytical toxicology 1979-09, Vol.3 (5), p.206-208
Main Authors: Blanke, R.V., Saady, J.J., Drummond, D.C., Weiss, J.N.
Format: Article
Language:English
Subjects:
Biopsy
Cornea
Drugs
Eye
Gas chromatography
High-performance liquid chromatography
Mass spectroscopy
Spectrophotometry
Thin-layer chromatography
U.V. radiation
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Description
Summary:Tilorone, an anti-tumor agent presently under investigation, appeared to be associated with corneal opacities. Attempts to measure levels of this drug in tissues from the eye required techniques of hiqh sensitivity. Applications of ultraviolet spectrophotometry, thin-layer chromatography (TLC), high-pressure liquid chromatography (HPLC), gas-liquid chromatography (GLC), and gas chromatography/mess spectrometry (GC/MS) to this drug are described. Tilorone was ultimately determined by GC/MS using selected ion monitoring (SIM).
ISSN:0146-4760
1945-2403
DOI:10.1093/jat/3.5.206