Analysis of regional compliance in a porcine model of acute lung injury

Highlights ► Acute lung injury leads to regional differences in morphology and alveolar dynamics. ► Imaging techniques are necessary to evaluate the lung state. ► Quantification was done by Volume Air Index, Heterogeneity Index and Circularity Index. ► EIT helps to identify regional heterogeneities...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2012-10, Vol.184 (1), p.16-26
Main Authors: Czaplik, Michael, Biener, Ingeborg, Dembinski, Rolf, Pelosi, Paolo, Soodt, Thomas, Schroeder, Wolfgang, Leonhardt, Steffen, Marx, Gernot, Rossaint, Rolf, Bickenbach, Johannes
Format: Article
Language:English
Subjects:
Acute lung injury
Acute Lung Injury - physiopathology
Animals
Disease Models, Animal
Electric Impedance
Electrical impedance tomography
Female
Hemodynamics - physiology
In vivo microscopy
Lung Compliance
Lung protective ventilation
Medical Education
Pulmonary/Respiratory
Regional compliance
Swine
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Summary:Highlights ► Acute lung injury leads to regional differences in morphology and alveolar dynamics. ► Imaging techniques are necessary to evaluate the lung state. ► Quantification was done by Volume Air Index, Heterogeneity Index and Circularity Index. ► EIT helps to identify regional heterogeneities and to estimate regional compliance. ► Analysis of regional pressure–volume-curves contribute to a clinical evaluation of ARDS.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2012.07.006