The antimicrobial and osteoinductive properties of silver nanoparticle/poly ( dl -lactic- co- glycolic acid)-coated stainless steel

Abstract Implant-associated bacterial infections are one of the most serious complications in orthopedic surgery. Treatment of these infections often requires multiple operations, device removal, long-term systemic antibiotics, and extended rehabilitation, and is frequently ineffective, leading to w...

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Bibliographic Details
Published in:Biomaterials 2012-12, Vol.33 (34), p.8745-8756
Main Authors: Liu, Yi, Zheng, Zhong, Zara, Janette N, Hsu, Chingyun, Soofer, Donnalisa E, Lee, Kevin S, Siu, Ronald K, Miller, Lloyd S, Zhang, Xinli, Carpenter, Doug, Wang, Chunling, Ting, Kang, Soo, Chia
Format: Article
Language:English
Subjects:
3T3 Cells
Advanced Basic Science
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antimicrobial osteoinductive
Bacteria - drug effects
Bacterial Infections - drug therapy
Bacterial Infections - etiology
Coated Materials, Biocompatible - chemistry
Coated Materials, Biocompatible - pharmacology
Dentistry
Femur - diagnostic imaging
Femur - growth & development
Femur - microbiology
Implant-associated infections
Lactic Acid - chemistry
Male
Mice
Nanoparticles - chemistry
Osteoblasts - cytology
Osteogenesis
Poly(dl-lactic-co-glycolic acid) (PLGA)
Polyglycolic Acid - chemistry
Prostheses and Implants - adverse effects
Radiography
Rats
Rats, Sprague-Dawley
Silver - chemistry
Silver - pharmacology
Silver nanoparticle
Silver nanoparticle/poly(dl-lactic-co-glycolic acid)-coated stainless steel alloy (SNPSA)
Stainless Steel - chemistry
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Summary:Abstract Implant-associated bacterial infections are one of the most serious complications in orthopedic surgery. Treatment of these infections often requires multiple operations, device removal, long-term systemic antibiotics, and extended rehabilitation, and is frequently ineffective, leading to worse clinical outcomes and increased financial costs. In this study, we evaluated s ilver n anoparticle/ p oly( dl -lactic- co- glycolic acid) (PLGA)-coated stainless s teel a lloy(SNPSA) as a potential antimicrobial implant material. We found that SNPSA exhibited strong antibacterial activity in vitro and ex vivo , and promoted MC3T3-E1 pre-osteoblasts proliferation and maturation in vitro . Furthermore, SNPSA implants induced osteogenesis while suppressing bacterial survival in contaminated rat femoral canals. Our results indicate that SNPSA has simultaneous antimicrobial and osteoinductive properties that make it a promising therapeutic material in orthopedic surgery.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2012.08.010