Efficacy of Fibrin Sealant for Drainage Reduction in Total Thyroidectomy with Bilateral Central Neck Dissection

Objective To investigate the efficacy of fibrin sealant (FS) for reducing postoperative drainage in patients who underwent total thyroidectomy (TT) with bilateral central neck dissection (CND) for papillary thyroid cancer. Study Design Prospective randomized trial. Setting Tertiary care institution....

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Bibliographic Details
Published in:Otolaryngology-head and neck surgery 2012-10, Vol.147 (4), p.654-660
Main Authors: Kim, Tae Wook, Choi, Sung Yong, Jang, Min-Seok, Lee, Gang-Gyu, Nam, Myung-Eun, Son, Young-Ik, Chung, Man Ki
Format: Article
Language:English
Subjects:
Carcinoma, Papillary - surgery
Chi-Square Distribution
complication
Double-Blind Method
drain
Drainage
Exudates and Transudates - chemistry
Female
fibrin sealant
Fibrin Tissue Adhesive - therapeutic use
Humans
Male
Middle Aged
Neck Dissection - methods
Postoperative Complications
Prospective Studies
surgery
thyroid
Thyroid Neoplasms - surgery
Thyroidectomy
Treatment Outcome
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Summary:Objective To investigate the efficacy of fibrin sealant (FS) for reducing postoperative drainage in patients who underwent total thyroidectomy (TT) with bilateral central neck dissection (CND) for papillary thyroid cancer. Study Design Prospective randomized trial. Setting Tertiary care institution. Subjects and Methods Seventy-eight patients with papillary thyroid cancer were enrolled and randomized to either the FS application group (FS+, 38 patients) or no FS application group (FS–, 40 patients). In both groups, postoperative drainage amounts were measured by a negative suction system until the criterion of drain removal was met. Drainage amounts as well as the time to drain removal, postoperative complications, and chemical profile assay of drain fluids between the 2 groups were performed. Results Drainage amounts at the initial 24 hours as well as total amounts of the FS+ group tended to be lower than those of the FS– group; however, they were not statistically different (at initial 24 hours, 64.3 ± 17.5 mL vs 73.0 ± 18.0 mL, P = .06; total amounts, 93.5 ± 30.7 mL vs 105.7 ± 31.2 mL, P = .05). The FS application did not shorten the time to drain removal even when different criteria for drain removal were applied (criteria of
ISSN:0194-5998
1097-6817
DOI:10.1177/0194599812449315