P-wave parameters and cardiac repolarization indices: Does menopausal status matter?

Abstract Background and purpose Data regarding electrocardiographic characteristics of postmenopausal women are lacking. In this prospective, cross-sectional study, electrocardiographic P-wave parameters and cardiac repolarization indices of age-matched pre- and postmenopausal healthy women were com...

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Bibliographic Details
Published in:Journal of cardiology 2012-10, Vol.60 (4), p.333-337
Main Authors: Dogan, Umuttan, MD, Dogan, Nasuh Utku, MD, Basarir, Ahmet Ozgur, MD, Yildirim, Serkan, MD, Celik, Cetin, MD, Incesu, Feyzanur, MD, Ozdemir, Kurtulus, MD
Format: Article
Language:English
Subjects:
Cardiac repolarization indices
Cardiovascular
Cross-Sectional Studies
Electrocardiography
Female
Heart Conduction System - physiology
Humans
Menopause
Menopause - physiology
Middle Aged
P-wave dispersion
Prospective Studies
Tpeak to Tend interval
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Summary:Abstract Background and purpose Data regarding electrocardiographic characteristics of postmenopausal women are lacking. In this prospective, cross-sectional study, electrocardiographic P-wave parameters and cardiac repolarization indices of age-matched pre- and postmenopausal healthy women were compared. We hypothesized that menopausal status would have a significant effect on cardiac electrical activity and hence electrocardiography (ECG) recordings. Materials and methods Twelve-lead ECG recordings were obtained from 125 consecutively recruited postmenopausal healthy women aged between 44 and 54 years. The control group consisted of 125 age-matched premenopausal women. P-wave parameters and cardiac repolarization indices were measured and compared with respect to menopausal status. Results Demographic features of premenopausal and postmenopausal women were comparable. There were no significant differences between two groups regarding mean values of heart rate, maximum and minimum P-wave duration, P-wave dispersion, maximum and minimum QT interval, and QT dispersion. Mean values of QT interval obtained from lead V5 were also similar. Corrected values which were calculated according to Bazett and Fridericia formulas also did not differ between the groups. Mean values of Tpeak to Tend (TpTe) ( p < 0.001) and corrected TpTe ( p = 0.001) intervals obtained from lead V5 were significantly shorter in postmenopausal women when compared to those without menopause. Conclusion Tpeak to Tend interval decreased significantly while QT intervals and P-wave parameters did not change in postmenopausal women when compared to premenopausal women. Association of these findings with changes in levels of sex steroids and their prognostic implications need to be elucidated with further studies.
ISSN:0914-5087
1876-4738
DOI:10.1016/j.jjcc.2012.04.001