From Metabolic Normality to Cardiometabolic Risk Factors in Subjects With Obesity

The aim of the study was to evaluate the 3 years incidence of cardiometabolic risk factors, such as impaired fasting glucose, reduced high‐density lipoprotein (HDL)‐cholesterol, increased plasma triglycerides or blood pressure as well as impaired glucose tolerance in overweight or obese (ow/ob) and...

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Published in:Obesity (Silver Spring, Md.) Md.), 2012-10, Vol.20 (10), p.2063-2069
Main Authors: Bobbioni‐Harsch, Elisabetta, Pataky, Zoltan, Makoundou, Vincent, Laville, Martine, Disse, Emmanuel, Anderwald, Christian, Konrad, Thomas, Golay, Alain
Format: Article
Language:English
Subjects:
Adult
Blood Pressure
Body Mass Index
Body Weight
Cardiovascular Diseases - blood
Cardiovascular Diseases - etiology
Cardiovascular Diseases - physiopathology
Cardiovascular system
Carotid Artery, Common - physiopathology
Carotid Intima-Media Thickness
Fasting - blood
Female
Glucose Intolerance - blood
Humans
Insulin Resistance
Lipoproteins, HDL - blood
Male
Metabolism
Middle Aged
Obesity
Obesity - blood
Obesity - complications
Obesity - physiopathology
Reference Values
Risk Factors
Young Adult
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Summary:The aim of the study was to evaluate the 3 years incidence of cardiometabolic risk factors, such as impaired fasting glucose, reduced high‐density lipoprotein (HDL)‐cholesterol, increased plasma triglycerides or blood pressure as well as impaired glucose tolerance in overweight or obese (ow/ob) and normal body weight (nbw) subjects metabolically normal at baseline. Subjects from the Relationship between Insulin Sensitivity and Cardiovascular Disease (RISC) study were analyzed. We analyzed 284 nbw and 152 ow/ob subjects who, at baseline, did not show any of the above‐mentioned cardiometabolic risk factors. At 3 years, these parameters were re‐evaluated. Intima‐media thickness (IMT) of the common carotid artery (CCA) was echographically measured. At follow‐up, the incidence of one or more cardiometabolic risk factors was 57.2% in ow/ob vs. 31.7% in nbw (P < 0.0001). After adjustment for age, sex, menopause status, lifestyle parameters, insulin sensitivity, and fasting insulinemia, BMI remained significantly linked to the development of one or more cardiometabolic risk factors (P = 0.02). An increased BMI at follow‐up was significantly associated with the development of cardiometabolic alterations, in both nbw and ow/ob groups (P = 0.04). Ow/ob subjects who, at 3 years follow‐up, remained metabolically normal, showed a less favourable cardiometabolic profile, when compared to nbw counterparts. In ow/ob metabolically normal males and females, intima‐media of the common carotid at follow‐up was thicker than in nbw (P = 0.03 for males, P = 0.04 for females). In conclusion, metabolically normal obese subjects show a higher incidence of cardiometabolic risk factors, in a short follow‐up period. Weight gain is significantly associated with the development of these factors, in both nbw and ow/ob subjects.
ISSN:1930-7381
1930-739X
DOI:10.1038/oby.2012.69