Comprehensive Gene Expression Analysis of Type B Trichothecenes

Type B trichothecenes, deoxynivalenol (DON) and nivalenol (NIV), are secondary metabolites of Fusarium species and are major pollutants in food and feed products. Recently, the production trend of their derivatives, 3-acetyldeoxynivalenol (3-AcDON), 15-acetyldeoxynivalenol (15-AcDON), and 4-acetylni...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2012-09, Vol.60 (37), p.9519-9527
Main Authors: Suzuki, Tadahiro, Iwahashi, Yumiko
Format: Article
Language:English
Subjects:
15-acetyldeoxynivalenol
3-acetyldeoxynivalenol
Biological and medical sciences
deoxynivalenol
feed contamination
feeds
Food Contamination
Food industries
Food toxicology
foods
Fundamental and applied biological sciences. Psychology
fusarenon-X
Fusarium
Fusarium - genetics
Fusarium - metabolism
Gene Expression
gene expression regulation
genes
mutants
Mutation
Mycotoxins
nivalenol
Oligonucleotide Array Sequence Analysis
Saccharomyces cerevisiae - drug effects
Saccharomyces cerevisiae - genetics
secondary metabolites
Structure-Activity Relationship
toxicity
Transcriptome
Trichothecenes - chemistry
Trichothecenes - genetics
Trichothecenes - toxicity
yeasts
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Summary:Type B trichothecenes, deoxynivalenol (DON) and nivalenol (NIV), are secondary metabolites of Fusarium species and are major pollutants in food and feed products. Recently, the production trend of their derivatives, 3-acetyldeoxynivalenol (3-AcDON), 15-acetyldeoxynivalenol (15-AcDON), and 4-acetylnivalenol (4-AcNIV or fusarenon-X), has been changing in various regions worldwide. Although in vivo behavior has been reported, it is necessary to acquire more detailed information about these derivatives. Here, the yeast PDR5 mutant was used for toxicity evaluation, and the growth test revealed that DON, 15-AcDON, and 4-AcNIV had higher toxicity compared to 3-AcDON and NIV. 15-AcDON exerted the most significant gene expression changes, and cellular localization clustering exhibited repression of mitochondrial ribosomal genes. This study suggests that the toxicity trends of both DON products (DON and its derivatives) and NIV products (NIV and its derivatives) are similar to those observed in mammalian cells, with a notable toxic response to 15-AcDON.
ISSN:0021-8561
1520-5118
DOI:10.1021/jf3020975