Transcranial direct current stimulation for the outpatient treatment of poor-responder depressed patients

Abstract Transcranial direct current stimulation (tDCS) is a selective, painless, brain stimulation technique that allows the electric stimulation of specific cortical regions. TDCS has been recently used as investigational intervention for major depression and treatment resistant depression (TRD) w...

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Bibliographic Details
Published in:European psychiatry 2012-10, Vol.27 (7), p.513-517
Main Authors: Dell’Osso, B, Zanoni, S, Ferrucci, R, Vergari, M, Castellano, F, D’Urso, N, Dobrea, C, Benatti, B, Arici, C, Priori, A, Altamura, A.C
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adult and adolescent clinical studies
Aged
Aged, 80 and over
Ambulatory Care
Augmentation
Biological and medical sciences
Bipolar Disorder - therapy
Brain
Brain stimulation
Depression
Depressive Disorder, Major - therapy
Depressive Disorder, Treatment-Resistant - therapy
Electric Stimulation Therapy - methods
Female
Humans
Internal Medicine
Male
Medical sciences
Middle Aged
Mood disorders
Outpatients
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Transcranial direct current stimulation (tDCS)
Treatment Outcome
Treatment-resistant depression (TRD)
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Summary:Abstract Transcranial direct current stimulation (tDCS) is a selective, painless, brain stimulation technique that allows the electric stimulation of specific cortical regions. TDCS has been recently used as investigational intervention for major depression and treatment resistant depression (TRD) with encouraging results. The present study was aimed to investigate the efficacy and tolerability of tDCS in major depressives with poor response to pharmacological treatment. Twenty-three depressed patients, with a diagnosis of major depressive disorder or bipolar disorder, were treated with augmentative tDCS for 5 days, two sessions per day in a blind-rater trial. The course of depressive symptoms was analyzed using repeated measures ANOVA for HAM-D and MADRS total scores. A qualitative analysis on the basis of the HAM-D response was performed as well. Both analyses were conducted at three time-points: T0 (baseline), T1 (endpoint tDCS) and T2 (end of the first week of follow-up). All patients completed the trial without relevant side-effects. A significant reduction of HAM-D and MADRS total scores was observed during the study ( P
ISSN:0924-9338
1778-3585
DOI:10.1016/j.eurpsy.2011.02.008